Rabbit anti-Human Dopamine Receptor, D4 Polyclonal Antibody | anti-DRD4 antibody

Dopamine Receptor, D4 (D4R)

Cat. Num. AAA618865

• Gene Names: DRD4; D4DR
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Dopamine Receptor; D4; Polyclonal Antibody; D4 (D4R); Anti -Dopamine Receptor; anti-DRD4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human D4R. No significant sequence homology with other dopamine receptors (D1, D2, D3 or D5).
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide

• Applicable Applications for anti-DRD4 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000-1:5000 (ECL).; ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
• Immunogen: Synthetic peptide corresponding to17aa near the N terminal, extracellular domain of human D4R, conjugated to KLH. Species Sequence Homology: monkey; 100%, mouse and rat; 57%
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-DRD4 antibody

Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B and D5) or D2-like (D2, D3 and D4). The two isoforms of D2R, D2 long (D2L) and short (D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains. A given cell or tissue may express more than one DR. Specific radioligands do not exist that can differentiate between these DR. Therefore, specific antibodies are needed to distinguish, localize, and document changes in DR levels in cells and tissues under various normal and pathological conditions. Dopamine D4 Receptor is a 467aa, G-protein coupled and transmembrane receptor protein.

Product Categories/Family for anti-DRD4 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 25360018
• NCBI GeneID: 1815
• UniProt Accession #: Q8IZB1; P21917; Q0MTB8; Q16303; Q76E76; Q8IZB2; Q8IZB3; Q8IZB4; Q8IZB5; Q8IZB6
• Molecular Weight: 13,655 Da
• NCBI Official Full Name: dopamine receptor D4
• NCBI Official Synonym Full Names: dopamine receptor D4
• NCBI Official Symbol: DRD4
• NCBI Official Synonym Symbols: D4DR
• NCBI Protein Information: D(4) dopamine receptor; D(4) dopamine receptor; OTTHUMP00000164435; dopamine D4 receptor; D(2C) dopamine receptor; seven transmembrane helix receptor
• UniProt Protein Name: Dopamine receptor D4
• Protein Family: D(4) dopamine receptor
• UniProt Gene Name: DRD4
• UniProt Entry Name: Q8IZB1_HUMAN

NCBI Description

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq]

Uniprot Description

DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; cell soma; integral to plasma membrane; plasma membrane; dendritic spine; terminal button; cell cortex; vesicle membrane

Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; protein binding; potassium channel regulator activity; dopamine receptor activity; dopamine binding; drug binding; SH3 domain binding

Biological Process: circadian rhythm; fear response; synaptic transmission, dopaminergic; behavioral fear response; positive regulation of dopamine uptake; activation of MAPK activity; short-term memory; adult locomotory behavior; positive regulation of kinase activity; regulation of neurotransmitter secretion; regulation of calcium-mediated signaling; behavioral response to ethanol; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; regulation of inhibitory postsynaptic membrane potential; negative regulation of cAMP biosynthetic process; behavioral response to cocaine; negative regulation of protein secretion; negative regulation of adenylate cyclase activity; response to amphetamine; regulation of dopamine metabolic process; social behavior; regulation of circadian rhythm; arachidonic acid secretion; cellular calcium ion homeostasis; olfactory learning; retina development in camera-type eye; response to steroid hormone stimulus; photoperiodism; dopamine receptor signaling pathway; positive regulation of sodium:hydrogen antiporter activity

Disease: Novelty Seeking Personality Trait; Attention Deficit-hyperactivity Disorder