Rabbit anti-Rat Dopamine Receptor, D4, aa176-185 Polyclonal Antibody | anti-DRD4 antibody
Dopamine Receptor, D4, aa176-185
Serum
Serum
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq]
Uniprot Description
DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cell soma; membrane; integral to plasma membrane; dendritic spine; plasma membrane; terminal button; vesicle membrane; cell cortex
Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; protein binding; potassium channel regulator activity; dopamine receptor activity; dopamine binding; drug binding; SH3 domain binding
Biological Process: circadian rhythm; synaptic transmission, dopaminergic; fear response; behavioral fear response; positive regulation of dopamine uptake; activation of MAPK activity; short-term memory; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of kinase activity; regulation of calcium-mediated signaling; behavioral response to ethanol; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; regulation of inhibitory postsynaptic membrane potential; negative regulation of cAMP biosynthetic process; behavioral response to cocaine; negative regulation of protein secretion; response to amphetamine; regulation of dopamine metabolic process; negative regulation of adenylate cyclase activity; social behavior; regulation of circadian rhythm; arachidonic acid secretion; cellular calcium ion homeostasis; olfactory learning; retina development in camera-type eye; response to steroid hormone stimulus; photoperiodism; dopamine receptor signaling pathway; positive regulation of sodium:hydrogen antiporter activity
Disease: Novelty Seeking Personality Trait; Attention Deficit-hyperactivity Disorder
Research Articles on DRD4
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Product Notes
The DRD4 drd4 (Catalog #AAA610068) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dopamine Receptor, D4, aa176-185 reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dopamine Receptor, D4, aa176-185 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot, ELISA and Immunohistochemistry., Recommended Dilutions:, Immunohistochemistry: 1:10,000 stains specific cells in various regions of PLP fixed rat brain sections This includes the glomeruli of the olfactory bulb, staining of cortex layer 4 and dendritic staining in cortex layers 2 and 3. In layer 5 of the cortex, apical dendrites of many neurons were stained. In the hippocampus, diffuse immunoreactivity was observed in the molecular layer of the dentate gyrus, with fine dots associated with many neurons in the granule cell layer., Western Blot: 1:500 using whole rat brain homogenate produced a band at ~48-53kD., Optimal dilutions to be determined by the researcher., Storage and Stability:, Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS, 10mg/ml BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Researchers should empirically determine the suitability of the DRD4 drd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dopamine Receptor, D4, aa176-185, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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