Rabbit Dopamine Receptor, D2, aa272-282 Polyclonal Antibody | anti-DRD2 antibody

Dopamine Receptor, D2, aa272-282

Cat. Num. AAA629711

• Gene Names: DRD2; D2R; D2DR
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Serum; Serum
• Synonyms: Dopamine Receptor; D2; aa272-282; Polyclonal Antibody; Anti -Dopamine Receptor; anti-DRD2 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Specific for D2 Dopamine Receptor (272-282). Detects two bands at ~48kD and ~51kD.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a lyophilized powder. Reconstitute with 100ul sterile PBS, 10mg/ml BSA.

• Applicable Applications for anti-DRD2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Immunocytochemistry, Western Blot and ELISA.; Dilution: Immunocytochemistry: 1:5000; Western Blot: 1:800; Optimal dilution determined by the researcher.
• Immunogen: D2 (aa272-282) covalently attached to a carrier protein.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS, 10mg/ml BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-DRD2 antibody

The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinson's disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.

Product Categories/Family for anti-DRD2 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 405310
• NCBI GeneID: 1813
• UniProt Accession #: P14416; Q9NZR3; Q9UPA9; Q59EH9; Q6LDH7
• Molecular Weight: 50,619 Da
• NCBI Official Full Name: D2 dopamine receptor
• NCBI Official Synonym Full Names: dopamine receptor D2
• NCBI Official Symbol: DRD2
• NCBI Official Synonym Symbols: D2R; D2DR
• NCBI Protein Information: D(2) dopamine receptor; D(2) dopamine receptor; OTTHUMP00000236612; OTTHUMP00000236613; OTTHUMP00000236614; OTTHUMP00000236615; OTTHUMP00000236616; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor
• UniProt Protein Name: D(2) dopamine receptor
• Protein Family: D(2) dopamine receptor
• UniProt Gene Name: DRD2
• UniProt Entry Name: DRD2_HUMAN

NCBI Description

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq]

Uniprot Description

DRD2: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: synaptic vesicle membrane; endocytic vesicle; axon; integral to plasma membrane; dendrite; postsynaptic density; acrosome; plasma membrane; dendritic spine; perikaryon; nerve terminal; lateral plasma membrane

Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein homodimerization activity; potassium channel regulator activity; protein heterodimerization activity; dopamine binding; drug binding

Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of dopamine uptake; prepulse inhibition; response to toxin; positive regulation of receptor internalization; positive regulation of multicellular organism growth; regulation of phosphoprotein phosphatase activity; thermoregulation; dopamine metabolic process; adult walking behavior; dopamine receptor, adenylate cyclase inhibiting pathway; negative regulation of insulin secretion; protein localization; phosphatidylinositol metabolic process; negative regulation of blood pressure; response to drug; response to light stimulus; response to inactivity; positive regulation of neuroblast proliferation; cerebral cortex GABAergic interneuron migration; negative regulation of synaptic transmission, glutamatergic; regulation of sodium ion transport; arachidonic acid secretion; regulation of synaptic transmission, GABAergic; positive regulation of growth hormone secretion; G-protein coupled receptor internalization; reduction of cytosolic calcium ion concentration; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; branching morphogenesis of a nerve; negative regulation of circadian sleep/wake cycle, sleep; response to morphine; locomotory behavior; behavioral response to ethanol; orbitofrontal cortex development; negative regulation of cell proliferation; synaptogenesis; behavioral response to cocaine; visual learning; adenohypophysis development; nerve-nerve synaptic transmission; feeding behavior; response to axon injury; circadian regulation of gene expression; negative regulation of dopamine secretion; negative regulation of cell migration; response to iron ion; associative learning; grooming behavior; positive regulation of cytokinesis; negative regulation of protein secretion; Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; striatum development; regulation of heart rate; regulation of cAMP metabolic process; regulation of potassium ion transport; sensory perception of smell; response to amphetamine; negative regulation of adenylate cyclase activity; auditory behavior; regulation of dopamine uptake; response to cocaine; cellular calcium ion homeostasis; regulation of systemic arterial blood pressure by neurological process; negative regulation of dopamine receptor signaling pathway; pigmentation; long-term memory; axonogenesis; positive regulation of G-protein coupled receptor protein signaling pathway; release of sequestered calcium ion into cytosol; response to hypoxia; regulation of synapse structural plasticity; dopamine receptor, phospholipase C activating pathway

Disease: Myoclonic Dystonia