Rabbit anti-Human Dopamine Receptor D1 Polyclonal Antibody | anti-DRD1 antibody

Dopamamine Receptor D1 Antibody

Cat. Num. AAA541387

• Gene Names: DRD1; DADR; DRD1A
• Reactivity: Human
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Synonyms: Dopamine Receptor D1; Polyclonal Antibody; Dopamamine Receptor D1 Antibody; D(1A) dopamine receptor; D1A dopamine receptor; DADR; Dopamine D1 receptor; DRD1A antibody; anti-DRD1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: Affinity Purified
• Concentration: 0.50-1.20 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 446

• Applicable Applications for anti-DRD1 antibody: Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Confocal Microscopy||1:200; Dot Blot: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:200; Immunofluorescence: 1:200; Immunohistochemistry: 1:200; Immunoprecipitation: 1:200; Western Blot: 1:2,500-1:5,000
• Immunogen: Synthetic peptide taken within amino acid region 290-340 on human D-1 dopamine receptor protein.
• Expression: Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.
• Determinant: C-epitope
• Molecular Function: angiotensin receptor binding;protein heterodimerization activity;protein phosphatase binding;ATPase binding
• Structure: Belongs to the G-protein coupled receptor 1 family has a Transmembrane helix domain
• Subcellular Location: Cell membrane;Endoplasmic Reticulum Membrane
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-DRD1 antibody

Affinity Purified D-1 dopamine receptor Antibody C-epitope
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Product Categories/Family for anti-DRD1 antibody

Primary Antibodies; Neuroscience; Neurotransmission; Dopamine Receptors; Dopamine Receptor D1 Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 30399
• NCBI GeneID: 1812
• UniProt Accession #: P18901; P21669; P21728
• Molecular Weight: 49,428 Da
• NCBI Official Full Name: D-1 dopamine receptor
• NCBI Official Synonym Full Names: dopamine receptor D1
• NCBI Official Symbol: DRD1
• NCBI Official Synonym Symbols: DADR; DRD1A
• NCBI Protein Information: D(1A) dopamine receptor
• UniProt Protein Name: D(1A) dopamine receptor
• Protein Family: D(1A) dopamine receptor
• UniProt Gene Name: Drd1
• UniProt Synonym Gene Names: Drd1a
• UniProt Entry Name: DRD1_RAT

NCBI Description

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Cellular Component: axon; caveola; cell soma; cytosol; dendrite; dendritic shaft; dendritic spine; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; integral to plasma membrane; membrane; nerve terminal; nonmotile primary cilium; nucleus; plasma membrane

Molecular Function: angiotensin receptor binding; ATPase binding; D3 dopamine receptor binding; dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity; drug binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; protein binding; protein complex binding; protein heterodimerization activity; protein phosphatase binding; receptor binding

Biological Process: adenylate cyclase activation; adult walking behavior; associative learning; astrocyte development; behavioral fear response; behavioral response to cocaine; calcium-mediated signaling; cellular response to insulin stimulus; cerebral cortex GABAergic interneuron migration; conditioned taste aversion; dentate gyrus development; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; dopamine transport; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; generation of action potential; glucose import; grooming behavior; habituation; hippocampus development; intracellular protein transport; learning; locomotory behavior; maternal behavior; mating behavior; memory; muscle contraction; negative regulation of cell migration; negative regulation of circadian sleep/wake cycle, sleep; negative regulation of protein kinase activity; operant conditioning; orbitofrontal cortex development; peristalsis; phosphatidylinositol catabolic process; phosphatidylinositol metabolic process; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of cell migration; positive regulation of membrane potential; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; protein import into nucleus; regulation of dopamine metabolic process; regulation of ion transport; regulation of long-term neuronal synaptic plasticity; regulation of vasoconstriction; response to activity; response to amino acid stimulus; response to amphetamine; response to cocaine; response to drug; response to estradiol stimulus; response to ethanol; response to food; response to morphine; response to nicotine; response to organic cyclic substance; response to organic nitrogen; response to retinoic acid; response to steroid hormone stimulus; sensitization; social behavior; startle response; striatum development; synaptic transmission, dopaminergic; synaptogenesis; thermoregulation; transmission of nerve impulse; vasodilation; visual learning