Rabbit Dopamine D4 Receptor (a.a. 176-185) Polyclonal Antibody | anti-DRD4 antibody
Rabbit anti D4 Dopamine Rec.
Specific for Dopamine D4 Receptor (a.a. 176-185). This antisera has been characterized by immunocytochemical, Western immunoblot and ELISA techniques.
Crossreactivity: D4 Dopamine Receptor (176-185) - 100%
D4 D
Reconstitute with 0.1ml of PBS which contains 10mg/ml BSA or with additional buffer for more dilute antisera.
Reconstituted: Aliquot and store at -20 degree C.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq]
Uniprot Description
Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subunit structure: Interacts with CLIC6
By similarity and GPRASP1. Ref.9
Subcellular location: Cell membrane; Multi-pass membrane protein.
Polymorphism: The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAL58637.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on DRD4
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Product Notes
The DRD4 drd4 (Catalog #AAA316179) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dopamine D4 Receptor (a.a. 176-185), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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