Rabbit anti-Human DOCK6 Polyclonal Antibody | anti-DOCK6 antibody

DOCK6 Rabbit Polyclonal

Cat. Num. AAA768728

• Gene Names: DOCK6; AOS2; ZIR1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DOCK6; Polyclonal Antibody; DOCK6 Rabbit Polyclonal; anti-DOCK6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 2047

• Applicable Applications for anti-DOCK6 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Dedicator of cytokinesis 6
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon slide using MBS768728 (DOCK6 Antibody) at dilution of 1:200)

Western Blot (WB)

(colo320 cells were subjected to SDS PAGE followed by western blot with MBS768728 (DOCK6 Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 157426887
• NCBI GeneID: 57572
• NCBI Accession #: NP_065863.2
• NCBI GenBank Nucleotide #: NM_020812.3
• Molecular Weight: 229,558 Da
• NCBI Official Full Name: dedicator of cytokinesis protein 6
• NCBI Official Synonym Full Names: dedicator of cytokinesis 6
• NCBI Official Symbol: DOCK6
• NCBI Official Synonym Symbols: AOS2; ZIR1
• NCBI Protein Information: dedicator of cytokinesis protein 6
• UniProt Protein Name: Dedicator of cytokinesis protein 6
• Protein Family: Dedicator of cytokinesis protein
• UniProt Gene Name: DOCK6
• UniProt Synonym Gene Names: KIAA1395
• UniProt Entry Name: DOCK6_HUMAN

NCBI Description

This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

Uniprot Description

DOCK6: Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth. Defects in DOCK6 are the cause of Adams-Oliver syndrome type 2 (AOS2). A disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. Belongs to the DOCK family.

Protein type: GEFs, misc.; Motility/polarity/chemotaxis; GEFs

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol; perinuclear region of cytoplasm

Molecular Function: guanyl-nucleotide exchange factor activity

Biological Process: blood coagulation; positive regulation of GTPase activity; small GTPase mediated signal transduction

Disease: Adams-oliver Syndrome 2