Western Blot (WB)
(Western blot analysis of anti-Dnmt2 Pab in Jurkat cell lysate (Lane A) and mouse liver tissue lysate (Lane B). Dnmt2 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)
Rabbit anti-Human, mouse Dnmt2 Polyclonal Antibody | anti-TRDMT1 antibody
Dnmt2 Antibody
Western Blot (WB)
(Western blot analysis of anti-Dnmt2 Pab in Jurkat cell lysate (Lane A) and mouse liver tissue lysate (Lane B). Dnmt2 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)
Western Blot (WB)
(Western blot analysis of anti-Dnmt2 Pab in Jurkat cell lysate (Lane A) and mouse liver tissue lysate (Lane B). Dnmt2 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Franchina, M., et al., Int. J. Biochem. Cell Biol. 33(11):1104-1115 (2001).
Dong, A., et al., Nucleic Acids Res. 29(2):439-448 (2001).
Yoder, J.A., et al., Hum. Mol. Genet. 7(2):279-284 (1998).
Van den Wyngaert, I., et al., FEBS Lett. 426(2):283-289 (1998).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
Uniprot Description
TRDMT1: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Belongs to the C5-methyltransferase family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.204; Methyltransferase; Methyltransferase, tRNA; Amino Acid Metabolism - cysteine and methionine
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: cytoplasm; nucleus
Molecular Function: DNA (cytosine-5-)-methyltransferase activity; DNA binding; RNA binding; tRNA methyltransferase activity
Biological Process: response to amphetamine; tRNA methylation
Research Articles on TRDMT1
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Product Notes
The TRDMT1 trdmt1 (Catalog #AAA9206809) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 346-375. The Dnmt2 Antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Dnmt2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the TRDMT1 trdmt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dnmt2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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