Rabbit anti-Human, Mouse DNM1 Polyclonal Antibody | anti-DNM1 antibody

DNM1 (Dynamin 1, DNM) (PE)

Cat. Num. AAA6414428

• Gene Names: DNM1; DNM
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: DNM1; Polyclonal Antibody; DNM1 (Dynamin 1; DNM) (PE); anti-DNM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes DNM1. Species Crossreactivity: human, mouse
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-DNM1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human DNM1.
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of Mouse brain, using DNM1 antibody.)

Product Categories/Family for anti-DNM1 antibody

Antibodies; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 56549117
• NCBI GeneID: 1759
• NCBI Accession #: NP_001005336.1
• NCBI GenBank Nucleotide #: NM_001005336.1
• UniProt Accession #: Q05193; Q5SYX0; Q5SYX2; Q6P3T6; Q86VD2; A6NLM6
• Molecular Weight: 97,408 Da
• NCBI Official Full Name: dynamin-1 isoform 2
• NCBI Official Synonym Full Names: dynamin 1
• NCBI Official Symbol: DNM1
• NCBI Official Synonym Symbols: DNM
• NCBI Protein Information: dynamin-1
• UniProt Protein Name: Dynamin-1
• Protein Family: Dynamin
• UniProt Gene Name: DNM1
• UniProt Synonym Gene Names: DNM
• UniProt Entry Name: DYN1_HUMAN

NCBI Description

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain.

Protein type: Microtubule-binding; Hydrolase; EC 3.6.5.5; Vesicle; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: microtubule; membrane coat; plasma membrane

Molecular Function: protein C-terminus binding; GTPase activity; identical protein binding; protein binding; GTP binding; protein complex binding; nitric-oxide synthase binding; protein kinase binding

Biological Process: axon guidance; receptor-mediated endocytosis; endosome organization and biogenesis; receptor internalization; ephrin receptor signaling pathway; endocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 31