Immunoprecipitation (IP)
(Immunoprecipitation of DNASE2 transfected lysate using DNASE2 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with DNASE2 purified mouse polyclonal antibody.)
Rabbit anti-Human DNASE2 Polyclonal Antibody | anti-DNASE2 antibody
DNASE2 (Deoxyribonuclease-2-alpha, Acid DNase, DNase II, R31240_2, Deoxyribonuclease II alpha, DNASE2A, DNL2)
Serum
Serum
Immunoprecipitation (IP)
(Immunoprecipitation of DNASE2 transfected lysate using DNASE2 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with DNASE2 purified mouse polyclonal antibody.)
Immunoprecipitation (IP)
(Immunoprecipitation of DNASE2 transfected lysate using DNASE2 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with DNASE2 purified mouse polyclonal antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.
Subcellular location: Lysosome.
Post-translational modification: Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect. Ref.11 Ref.12 Ref.14
Miscellaneous: Not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells, but for the degradation of DNA from dying cells
By similarity.
Sequence similarities: Belongs to the DNase II family.
Research Articles on DNASE2
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Product Notes
The DNASE2 dnase2 (Catalog #AAA648334) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DNASE2 (Deoxyribonuclease-2-alpha, Acid DNase, DNase II, R31240_2, Deoxyribonuclease II alpha, DNASE2A, DNL2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DNASE2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Suitable for use in Western Blot and Immunoprecipitation. Researchers should empirically determine the suitability of the DNASE2 dnase2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGVLLL DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW VYNYQLEGIF AQEFPDLENV VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS GWLAAALGTN LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM ARKPSRAYKI. It is sometimes possible for the material contained within the vial of "DNASE2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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