Western Blot (WB)
(Western blot analysis of DNAJC19 Antibody (Center) in mouse kidney tissue lysates (35ug/lane). DNAJC19 (arrow) was detected using the purified Pab.)
Rabbit anti-Human, mouse DNAJC19 Polyclonal Antibody | anti-DNAJC19 antibody
DNAJC19 Antibody (Center)
Western Blot (WB)
(Western blot analysis of DNAJC19 Antibody (Center) in mouse kidney tissue lysates (35ug/lane). DNAJC19 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of DNAJC19 Antibody (Center) in mouse kidney tissue lysates (35ug/lane). DNAJC19 (arrow) was detected using the purified Pab.)
Davey,K.M., J. Med. Genet. 43 (5), 385-393 (2006)
Mokranjac,D., EMBO J. 22 (19), 4945-4956 (2003)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012]
Uniprot Description
DNAJC19: Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity. Defects in DNAJC19 are the cause of 3-methylglutaconic aciduria type 5 (MGA5); also known as dilated cardiomyopathy with ataxia (DCMA). MGA5 is an autosomal recessive disorder characterized by early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays, testicular dysgenesis, growth failure, and significant increases in urine organic acids, particularly 3-methylglutaconic acid and 3-methylglutaric acid. Belongs to the TIM14 family.
Protein type: Membrane protein, integral; Mitochondrial; Chaperone
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component: protein complex; mitochondrion; mitochondrial inner membrane; integral to membrane
Molecular Function: protein binding
Biological Process: genitalia development; cellular protein metabolic process; visual perception; protein folding; protein targeting to mitochondrion
Disease: 3-methylglutaconic Aciduria, Type V
Research Articles on DNAJC19
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Product Notes
The DNAJC19 dnajc19 (Catalog #AAA9205019) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 55-84. The DNAJC19 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DNAJC19 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DNAJC19 dnajc19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNAJC19, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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