Rabbit anti-Human DNAJB6 Polyclonal Antibody | anti-DNAJB6 antibody

DNAJB6 (HSJ2, MRJ, MSJ1, DnaJ Homolog Subfamily B Member 6, HHDJ1, Heat Shock Protein J2, HSJ-2, MSJ-1, MGC1152, MGC117297, DKFZp566D0824, FLJ42837) (AP)

Cat. Num. AAA6376436

• Gene Names: DNAJB6; DJ4; MRJ; DnaJ; HSJ2; HHDJ1; HSJ-2; MSJ-1; LGMD1D; LGMD1E
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DNAJB6; Polyclonal Antibody; DNAJB6 (HSJ2; MRJ; MSJ1; DnaJ Homolog Subfamily B Member 6; HHDJ1; Heat Shock Protein J2; HSJ-2; MSJ-1; MGC1152; MGC117297; DKFZp566D0824; FLJ42837) (AP); anti-DNAJB6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DNAJB6.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-DNAJB6 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human DNAJB6, aa1-326 (NP_490647.1).
• Immunogen Sequence: MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGSFFSAFSGFPSFGSGFSSFDTGFTSFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVEEDGQLKSLTINGVADDDALAEERMRRGQNALPAQPAGLRPPKPPRPASLLRHAPHCLSEEEGEQDRPRAPGPWDPLASAAGLKEGGKRKKQKQREESKKKKSTKGNH
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(DNAJB6 rabbit polyclonal antibody. Western Blot analysis of DNAJB6 expression in HepG2.)

Western Blot (WB)

(Western Blot analysis of DNAJB6 expression in transfected 293T cell line by DNAJB6 polyclonal antibody. Lane 1: DNAJB6 transfected lysate (36.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-DNAJB6 antibody

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.

Product Categories/Family for anti-DNAJB6 antibody

Antibodies; Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 17388799
• NCBI GeneID: 10049
• NCBI Accession #: NP_490647.1
• NCBI GenBank Nucleotide #: NM_058246.3
• Molecular Weight: 30,369 Da
• NCBI Official Full Name: dnaJ homolog subfamily B member 6 isoform a
• NCBI Official Synonym Full Names: DnaJ heat shock protein family (Hsp40) member B6
• NCBI Official Symbol: DNAJB6
• NCBI Official Synonym Symbols: DJ4; MRJ; DnaJ; HSJ2; HHDJ1; HSJ-2; MSJ-1; LGMD1D; LGMD1E
• NCBI Protein Information: dnaJ homolog subfamily B member 6
• Protein Family: DnaJ homolog subfamily

NCBI Description

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]