Rabbit DNAI1 Polyclonal Antibody | anti-DNAI1 antibody

DNAI1 Rabbit Polyclonal

Cat. Num. AAA768669

• Gene Names: DNAI1; PCD; DIC1; ICS1; CILD1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DNAI1; Polyclonal Antibody; DNAI1 Rabbit Polyclonal; anti-DNAI1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 703

• Applicable Applications for anti-DNAI1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Dynein, axonemal, intermediate chain 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(human brain tissue were subjected to SDS PAGE followed by western blot with MBS768669 (DNAI1 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 526479830
• NCBI GeneID: 27019
• NCBI Accession #: NP_001268357.1
• NCBI GenBank Nucleotide #: NM_001281428.1
• Molecular Weight: 19,284 Da
• NCBI Official Full Name: dynein intermediate chain 1, axonemal isoform 2
• NCBI Official Synonym Full Names: dynein axonemal intermediate chain 1
• NCBI Official Symbol: DNAI1
• NCBI Official Synonym Symbols: PCD; DIC1; ICS1; CILD1
• NCBI Protein Information: dynein intermediate chain 1, axonemal
• UniProt Protein Name: Dynein intermediate chain 1, axonemal
• Protein Family: Dynein
• UniProt Gene Name: DNAI1
• UniProt Entry Name: DNAI1_HUMAN

NCBI Description

This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

DNAI1: Part of the dynein complex of respiratory cilia. Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1). CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAI1 are the cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein intermediate chain family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cilium; cytoplasm; cytoskeleton; microtubule

Molecular Function: motor activity; protein binding

Biological Process: determination of left/right symmetry; metabolic process; sperm motility

Disease: Ciliary Dyskinesia, Primary, 1