Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using DNA Polymerase theta antibody.)
Rabbit anti-Human DNA Polymerase theta Polyclonal Antibody | anti-POLQ antibody
DNA Polymerase theta Antibody
Gene Names
POLQ; POLH; PRO0327
Reactivity
Human
Applications
Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
DNA Polymerase theta; Polyclonal Antibody; DNA Polymerase theta Antibody; DNA polymerase theta; EC 2.7.7.7; DNA polymerase eta; POLQ; POLH; anti-POLQ antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total DNA Polymerase theta protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
2590
Applicable Applications for anti-POLQ antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:50~1:100
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human DNA Polymerase theta.
Target Name
DNA Polymerase theta
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using DNA Polymerase theta antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using DNA Polymerase theta antibody.)
Related Product Information for anti-POLQ antibody
Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.Sharief F.S., Genomics 59:90-96(1999).Harris P.V., Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Product Categories/Family for anti-POLQ antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
197,541 Da
NCBI Official Full Name
DNA polymerase theta
NCBI Official Synonym Full Names
polymerase (DNA directed), theta
NCBI Official Symbol
POLQ
NCBI Official Synonym Symbols
POLH; PRO0327
NCBI Protein Information
DNA polymerase theta
UniProt Protein Name
DNA polymerase theta
Protein Family
UniProt Gene Name
POLQ
UniProt Entry Name
DPOLQ_HUMAN
Uniprot Description
POLQ: Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links. Belongs to the DNA polymerase type-A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.7.7.7; DNA repair, damage
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: nucleoplasm
Molecular Function: damaged DNA binding; DNA-directed DNA polymerase activity; ATP binding; single-stranded DNA-dependent ATPase activity
Biological Process: DNA repair; DNA-dependent DNA replication
Research Articles on POLQ
Similar Products
Product Notes
The POLQ polq (Catalog #AAA9406249) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DNA Polymerase theta Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DNA Polymerase theta can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the POLQ polq for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNA Polymerase theta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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