Rabbit anti-Human DLGAP4 Polyclonal Antibody | anti-DLGAP4 antibody

DLGAP4, NT (DLGAP4, DAP4, KIAA0964, SAPAP4, Disks large-associated protein 4, PSD-95/SAP90-binding protein 4, SAP90/PSD-95-associated protein 4) (FITC)

Cat. Num. AAA6292336

• Gene Names: DLGAP4; DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DLGAP4; Polyclonal Antibody; NT (DLGAP4; DAP4; KIAA0964; SAPAP4; Disks large-associated protein 4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4) (FITC); SAP90/PSD-95-associated protein 4; anti-DLGAP4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-DLGAP4 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: DLGAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human DLGAP4.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DLGAP4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the DLGAP4 antibody detected the DLGAP4 protein (arrow).)

Related Product Information for anti-DLGAP4 antibody

DLGAP4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-DLGAP4 antibody

Antibodies; Binding Proteins

References

Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009): Rikova, K., et al. Cell 131(6):1190-1203(2007). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Grelle, G., et al. Mol. Cell Proteomics 5(2):234-244(2006). Kawabe, H., et al. J. Biol. Chem. 274(43):30914-30918(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 109891938
• NCBI GeneID: 22839
• NCBI Accession #: NP_001035951.1; NP_055717.2; NP_892118.1
• NCBI GenBank Nucleotide #: NM_001042486.3
• UniProt Accession #: Q9Y2H0; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; E1P5T5
• Molecular Weight: 108,012 Da
• NCBI Official Full Name: disks large-associated protein 4 isoform c
• NCBI Official Synonym Full Names: discs, large (Drosophila) homolog-associated protein 4
• NCBI Official Symbol: DLGAP4
• NCBI Official Synonym Symbols: DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4
• NCBI Protein Information: disks large-associated protein 4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4
• UniProt Protein Name: Disks large-associated protein 4
• Protein Family: Disks large-associated protein
• UniProt Gene Name: DLGAP4
• UniProt Synonym Gene Names: DAP4; KIAA0964; SAPAP4; DAP-4; SAPAP-4
• UniProt Entry Name: DLGP4_HUMAN

Uniprot Description

SAPAP4: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: membrane; synapse

Molecular Function: protein binding

Biological Process: cell-cell signaling