Rabbit DLG4 Polyclonal Antibody | anti-DLG4 antibody

DLG4 Antibody (C-erm)

Cat. Num. AAA9215624

• Gene Names: DLG4; PSD95; SAP90; SAP-90
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Synonyms: DLG4; Polyclonal Antibody; DLG4 Antibody (C-erm); Purified Rabbit Polyclonal Antibody (Pab); Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90; PSD95; anti-DLG4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This DLG4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 548-579 amino acids from human DLG4.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 721

• Applicable Applications for anti-DLG4 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-DLG4 Antibody (C-erm) at 1:2000 dilutionLane 1: human brain lysateLane 2: mouse brain lysateLane 3: mouse cerebellum lysateLane 4: rat brain lysateLane 5: rat cerebellum lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 80 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-DLG4 antibody

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

Product Categories/Family for anti-DLG4 antibody

Neuroscience

References

Stathakis D.G.,et al.Genomics 44:71-82(1997). Stathakis D.G.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases. Stathakis D.G.,et al.J. Neurochem. 73:2250-2265(1999). Ota T.,et al.Nat. Genet. 36:40-45(2004). Zody M.C.,et al.Nature 440:1045-1049(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 192447426
• NCBI GeneID: 1742
• NCBI Accession #: NP_001122299.1
• NCBI GenBank Nucleotide #: NM_001128827.1
• UniProt Accession #: P78352; Q92941; Q9UKK8; B7Z1S1; G5E939
• Molecular Weight: 80495
• NCBI Official Full Name: disks large homolog 4 isoform 2
• NCBI Official Synonym Full Names: discs, large homolog 4 (Drosophila)
• NCBI Official Symbol: DLG4
• NCBI Official Synonym Symbols: PSD95; SAP90; SAP-90
• NCBI Protein Information: disks large homolog 4
• UniProt Protein Name: Disks large homolog 4
• Protein Family: Disks large
• UniProt Gene Name: DLG4
• UniProt Synonym Gene Names: PSD95; PSD-95; SAP-90; SAP90
• UniProt Entry Name: DLG4_HUMAN

NCBI Description

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B ().