Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/40.)
Rabbit anti-Human DLG2 Polyclonal Antibody | anti-DLG2 antibody
DLG2 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/40.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/40.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Uniprot Description
PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; membrane; basolateral plasma membrane; postsynaptic density; plasma membrane; ionotropic glutamate receptor complex; cell junction
Molecular Function: ionotropic glutamate receptor binding; guanylate kinase activity; protein binding
Biological Process: establishment and/or maintenance of epithelial cell polarity; nervous system development; synaptic transmission; sensory perception of pain; receptor clustering; nucleotide phosphorylation
Research Articles on DLG2
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Product Notes
The DLG2 dlg2 (Catalog #AAA9407935) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DLG2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DLG2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:50-1:200. Researchers should empirically determine the suitability of the DLG2 dlg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DLG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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