Rabbit anti-Human DLEC1 Polyclonal Antibody | anti-DLEC1 antibody

DLEC1, NT (DLEC1, DLC1, Deleted in lung and esophageal cancer protein 1, Deleted in lung cancer protein 1)

Cat. Num. AAA641908

• Gene Names: DLEC1; F56; DLC1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: DLEC1; Polyclonal Antibody; NT (DLEC1; DLC1; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1); Anti -DLEC1; anti-DLEC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-DLEC1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: DLEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-292 amino acids from the N-terminal region of human DLEC1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DLEC1 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DLEC1 antibody detected the DLEC1 protein (arrow).)

Related Product Information for anti-DLEC1 antibody

This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney.

Product Categories/Family for anti-DLEC1 antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 90669228
• NCBI GeneID: 9940
• NCBI Accession #: NP_031363.2
• NCBI GenBank Nucleotide #: NM_007337.2
• UniProt Accession #: Q9Y238; Q9NSW0; Q9NTG5
• Molecular Weight: 195,684 Da
• NCBI Official Full Name: deleted in lung and esophageal cancer protein 1 isoform DLEC1-S3
• NCBI Official Synonym Full Names: deleted in lung and esophageal cancer 1
• NCBI Official Symbol: DLEC1
• NCBI Official Synonym Symbols: F56; DLC1
• NCBI Protein Information: deleted in lung and esophageal cancer protein 1; DLC-1; deleted in lung and esophageal cancer 1 transcript varient 2
• UniProt Protein Name: Deleted in lung and esophageal cancer protein 1
• Protein Family: Deleted in lung and esophageal cancer protein
• UniProt Gene Name: DLEC1
• UniProt Synonym Gene Names: DLC1; DLC-1
• UniProt Entry Name: DLEC1_HUMAN

NCBI Description

This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]

Uniprot Description

DLEC1: May act as a tumor suppressor by inhibiting cell proliferation. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR). Defects in DLEC1 are a cause of lung cancer (LNCR). A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer. Defects in DLEC1 are a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of esophageal cancer. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasm

Biological Process: negative regulation of cell proliferation

Disease: Lung Cancer; Esophageal Cancer