Immunohistochemistry (IHC)
(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Mouse, Human DKK2 Polyclonal Antibody | anti-DKK2 antibody
Anti-DKK2 Antibody (aa31-62) IHC-plus
WB (1:1000)
For long term storage store at -20 degree C.
Immunohistochemistry (IHC)
(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
Western Blot (WB)
(DKK2 Antibody (T46) western blot of mouse brain tissue lysates (35 ug/lane). The DKK2 antibody detected the DKK2 protein (arrow).)
Western Blot (WB)
(DKK2 Antibody (T46) western blot of mouse brain tissue lysates (35 ug/lane). The DKK2 antibody detected the DKK2 protein (arrow).)
Western Blot (WB)
(Western blot of DKK2 (arrow) using DKK2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DKK2 gene (Lane 2) (Origene Technologies).)
Western Blot (WB)
(Western blot of DKK2 (arrow) using DKK2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DKK2 gene (Lane 2) (Origene Technologies).)
Western Blot (WB)
(The anti-DKK2 antibody is used in Western blot to detect DKK2 in Jurkat cell lysate.)
Western Blot (WB)
(The anti-DKK2 antibody is used in Western blot to detect DKK2 in Jurkat cell lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
Uniprot Description
DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family.
Protein type: Inhibitor; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: extracellular space
Biological Process: multicellular organismal development; Wnt receptor signaling pathway
Research Articles on DKK2
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Product Notes
The DKK2 dkk2 (Catalog #AAA249500) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DKK2 Antibody (aa31-62) IHC-plus reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's DKK2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P (1:100) WB (1:1000). Researchers should empirically determine the suitability of the DKK2 dkk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DKK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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