Western Blot (WB)
(Western Blot: Sample: Human Lung Tissue.)
Rabbit anti-Human Dishevelled, Dsh Homolog 1 (DVL1) Polyclonal Antibody | anti-DVL1 antibody
Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- R RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Human Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Human Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant DVL1, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant DVL1, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:Human Glioma Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:Human Glioma Tissue.)
NCBI and Uniprot Product Information
NCBI Description
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
Uniprot Description
DVL1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs to the DSH family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: axon; cell soma; clathrin-coated vesicle; cytoplasmic vesicle; cytosol; dendritic spine; growth cone; lateral plasma membrane; microtubule; neuron projection; postsynaptic density; synapse
Molecular Function: beta-catenin binding; enzyme binding; frizzled binding; identical protein binding; protein binding; protein kinase binding; Rac GTPase binding
Biological Process: axon extension; axon guidance; collateral sprouting; convergent extension involved in neural plate elongation; cytoplasmic microtubule organization; dendrite morphogenesis; heart development; negative regulation of protein binding; negative regulation of protein kinase activity; neural tube development; neuromuscular junction development; neurotransmitter secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of transcription, DNA-templated; positive regulation of Wnt receptor signaling pathway; prepulse inhibition; protein stabilization; receptor clustering; regulation of neurotransmitter levels; social behavior; synapse organization; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Robinow Syndrome, Autosomal Dominant; Robinow Syndrome, Autosomal Dominant 2
Research Articles on DVL1
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Product Notes
The DVL1 dvl1 (Catalog #AAA2017840) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Dishevelled, Dsh Homolog 1 (DVL1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Dishevelled, Dsh Homolog 1 (DVL1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the DVL1 dvl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- R RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI. It is sometimes possible for the material contained within the vial of "Dishevelled, Dsh Homolog 1 (DVL1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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