Western Blot (WB)
(Western blot detection of Dishevelled 2 (Phospho-Ser143) in K562 cell lysates using Dishevelled 2 (Phospho-Ser143) Rabbit pAb(1:1000 diluted). Predicted band size:79kDa. Observed band size:90-95kDa.)
Rabbit anti-Human, Mouse Dishevelled 2 Polyclonal Antibody | anti-DVL2 antibody
Phospho-Dishevelled 2 (Ser143) Rabbit pAb
Western Blot (WB)
(Western blot detection of Dishevelled 2 (Phospho-Ser143) in K562 cell lysates using Dishevelled 2 (Phospho-Ser143) Rabbit pAb(1:1000 diluted). Predicted band size:79kDa. Observed band size:90-95kDa.)
Western Blot (WB)
(Western blot detection of Dishevelled 2 (Phospho-Ser143) in K562 cell lysates using Dishevelled 2 (Phospho-Ser143) Rabbit pAb(1:1000 diluted). Predicted band size:79kDa. Observed band size:90-95kDa.)
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Uniprot Description
DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: apical part of cell; cytoplasm; plasma membrane; cytoplasmic vesicle; clathrin-coated endocytic vesicle; nucleus; cytosol
Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein self-association; frizzled binding
Biological Process: segment specification; transcription from RNA polymerase II promoter; positive regulation of JNK activity; Wnt receptor signaling pathway; convergent extension involved in neural plate elongation; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; heart development; neural tube closure; positive regulation of transcription factor activity; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation
Research Articles on DVL2
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Product Notes
The DVL2 dvl2 (Catalog #AAA4751919) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-Dishevelled 2 (Ser143) Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Dishevelled 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the DVL2 dvl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dishevelled 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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