Goat Dis3L2 Polyclonal Antibody | anti-Dis3L2 antibody

Dis3L2 Polyclonal Antibody

Cat. Num. AAA448159

• Reactivity: Drosophila proteins
• Applications: Western Blot
• Purity: Epitope affinity purified
• Synonyms: Dis3L2; Polyclonal Antibody; Dis3L2 Polyclonal Antibody; Anti-Dis3L2; CG16940; Dis3 like 3'-5' exoribonuclease 2; dmdis3l2; dmDis3l2; Dmel\CG16940 antibody; anti-Dis3L2 antibody

• Host: Goat
• Reactivity: Drosophila proteins
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Detects endogenous levels of Dis3L2 in Drosophila protein extracts by Western blot.
• Purity/Purification: Epitope affinity purified
• Form/Format: Polyclonal antibody supplied as a 100ul (3mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
• Sequence Length: 603

• Applicable Applications for anti-Dis3L2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2,000
• Immunogen: Recombinant peptide derived from within residues 430 aa to the N-terminus of Drosophila melanogaster protein in E. coli.
• Conjugation: Unconjugated
• Antigen: Recombinant peptide derived from within residues 430 aa to the N-terminus of Drosophila melanogaster protein in E. coli.
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: Store at -20 degree C for long-term storage. Store at 2-8 degree C for up to one month.; For continuous use, store at 2-8 degree C for one-two days. For extended storage, store in -20 degree C freezer. Working dilution samples should be discarded if not used within 12 hours.; Avoid freeze/thaw cycles.

Reactivity Information

Western Blot (WB)

Related Product Information for anti-Dis3L2 antibody

DIS3-like exonuclease 2
Goat polyclonal antibody to Dis3L2. Dis3L2 is an exoribonuclease from the RNase II/RNB family which degrades RNAs in a 3'-5' direction. This protein has been implicated in cellular proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 381214351
• NCBI GenBank Nucleotide #: NP_001244210.1
• UniProt Accession #: Q8IYB7
• NCBI Official Full Name: DIS3-like exonuclease 2 isoform 2
• UniProt Protein Name: DIS3-like exonuclease 2
• Protein Family: DIS3-like exonuclease
• UniProt Gene Name: DIS3L2
• UniProt Synonym Gene Names: hDIS3L2
• UniProt Entry Name: DI3L2_HUMAN

Uniprot Description

DIS3L2: Ribonuclease that plays a critical role in RNA metabolism. It is essential for correct mitosis, and negatively regulates cell proliferation. Defects in DIS3L2 are the cause of Perlman syndrome (PRLMNS). An autosomal recessive congenital overgrowth syndrome. Affected children are large at birth, are hypotonic, and show organomegaly, characteristic facial dysmorphisms (inverted V-shaped upper lip, prominent forehead, deep-set eyes, broad and flat nasal bridge, and low-set ears), renal anomalies (nephromegaly and hydronephrosis), frequent neurodevelopmental delay, and high neonatal mortality. Perlman syndrome is associated with a high risk of Wilms tumor. Histologic examination of the kidneys in affected children shows frequent nephroblastomatosis, which is a precursor lesion for Wilms tumor. Belongs to the RNR ribonuclease family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.13.-; Ribonuclease; Tumor suppressor

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytoplasm; nuclear exosome (RNase complex); polysome

Molecular Function: 3'-5'-exoribonuclease activity; magnesium ion binding; poly(U) binding; protein binding; ribonuclease activity

Biological Process: cell division; mitosis; mitotic sister chromatid separation; mRNA catabolic process, exonucleolytic; negative regulation of cell proliferation; rRNA catabolic process; rRNA processing; stem cell maintenance

Disease: Perlman Syndrome