Rabbit anti-Human, Mouse DIO2 Polyclonal Antibody | anti-DIO2 antibody

DIO2 Conjugated Antibody

Cat. Num. AAA9447975

• Gene Names: DICER1; DCR1; GLOW; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
• Reactivity: Human, Mouse
• Applications: Most Applications
• Synonyms: DIO2; Polyclonal Antibody; DIO2 Conjugated Antibody; D2; 5DII; SelY; DIOII; TXDI2; anti-DIO2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total DIO2 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Sequence Length: 1922

• Applicable Applications for anti-DIO2 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human deiodinase, iodothyronine, type II
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-DIO2 antibody

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3, 3', 5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 29294649
• NCBI GeneID: 23405
• NCBI Accession #: NP_085124
• NCBI GenBank Nucleotide #: NP_085124.2
• UniProt Accession #: Q92813; Q9UPY3
• Molecular Weight: 31
• NCBI Official Full Name: endoribonuclease Dicer isoform 1
• NCBI Official Synonym Full Names: dicer 1, ribonuclease III
• NCBI Official Symbol: DICER1
• NCBI Official Synonym Symbols: DCR1; GLOW; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
• NCBI Protein Information: endoribonuclease Dicer
• UniProt Protein Name: Type II iodothyronine deiodinase
• Protein Family: Type II iodothyronine deiodinase
• UniProt Gene Name: DIO2
• UniProt Synonym Gene Names: ITDI2; TXDI2

NCBI Description

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Uniprot Description

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.