Rabbit DHPS Polyclonal Antibody | anti-DHPS antibody

DHPS (Deoxyhypusine Synthase, DS, DHS, MIG13) (FITC)

Cat. Num. AAA6446132

• Gene Names: DHPS; DS; DHS; MIG13
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: DHPS; Polyclonal Antibody; DHPS (Deoxyhypusine Synthase; DS; DHS; MIG13) (FITC); anti-DHPS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DHPS. Species Crossreactivity: Mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-DHPS antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human DHPS.
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-DHPS antibody

Antibodies; Enzymes; Synthase

NCBI and Uniprot Product Information

• NCBI GI #: 4503325
• NCBI GeneID: 1725
• NCBI Accession #: NP_001921.1
• NCBI GenBank Nucleotide #: NM_001930.3
• UniProt Accession #: P49366; Q13184; Q13276; Q9UDG0; A8K688
• Molecular Weight: 40,971 Da
• NCBI Official Full Name: deoxyhypusine synthase isoform a
• NCBI Official Synonym Full Names: deoxyhypusine synthase
• NCBI Official Symbol: DHPS
• NCBI Official Synonym Symbols: DS; DHS; MIG13
• NCBI Protein Information: deoxyhypusine synthase; migration-inducing gene 13
• UniProt Protein Name: Deoxyhypusine synthase
• UniProt Gene Name: DHPS
• UniProt Synonym Gene Names: DS; DHS
• UniProt Entry Name: DHYS_HUMAN

NCBI Description

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

Uniprot Description

DHPS: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. Belongs to the deoxyhypusine synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 2.5.1.46; Transferase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol

Molecular Function: protein binding; deoxyhypusine synthase activity

Biological Process: cellular protein metabolic process; translation; positive regulation of cell proliferation; positive regulation of T cell proliferation; hypusine biosynthetic process from peptidyl-lysine; post-translational protein modification; glucose homeostasis; spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase; protein homotetramerization