Western Blot (WB)
(Western Blot analysis of NCI-H460 cell line lysates (35ug/lane) using MBS649543 . DGAT2 (arrow) was detected using MBS649543.)
Rabbit anti-Human DGAT2 Polyclonal Antibody | anti-DGAT2 antibody
DGAT2, NT (DGAT2, Diacylglycerol O-acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, Diglyceride acyltransferase 2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(Western Blot analysis of NCI-H460 cell line lysates (35ug/lane) using MBS649543 . DGAT2 (arrow) was detected using MBS649543.)
Western Blot (WB)
(Western Blot analysis of NCI-H460 cell line lysates (35ug/lane) using MBS649543 . DGAT2 (arrow) was detected using MBS649543.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides
By similarity. Functions also as an acyl-CoA retinol acyltransferase (ARAT).
Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. Ref.9Acyl-CoA + retinol = CoA + retinyl ester. Ref.9
Enzyme regulation: Inhibited by niacin
By similarity.
Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.
Subunit structure: Forms multimeric complexes consisting of several DGAT2 subunits
By similarity.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet
By similarity Ref.2.
Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. Ref.1 Ref.2
Sequence similarities: Belongs to the diacylglycerol acyltransferase family.
Sequence caution: The sequence BAD38635.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD38961.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on DGAT2
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Product Notes
The DGAT2 dgat2 (Catalog #AAA649543) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DGAT2, NT (DGAT2, Diacylglycerol O-acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, Diglyceride acyltransferase 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DGAT2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the DGAT2 dgat2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DGAT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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