Guinea Pig Desmoplakin Polyclonal Antibody | anti-desmoplakin antibody
Desmoplakin antibody
Reactivity
The antiserum shows distinct punctate membrane staining of epithelia. In western blot analysis the antiserum reacts specifically with desmoplakin 1 polypeptide. Reacts to human carcinoma cell lines: MCF-7, A-431, HaCaT, CaCo2
Applications
Immunofluorescence, Immunohistochemistry, Western Blot
Purity
> 95% pure
Synonyms
Desmoplakin; Polyclonal Antibody; Desmoplakin antibody; Polyclonal Desmoplakin; Anti-Desmoplakin; anti-desmoplakin antibody
Host
Guinea Pig
Reactivity
The antiserum shows distinct punctate membrane staining of epithelia. In western blot analysis the antiserum reacts specifically with desmoplakin 1 polypeptide. Reacts to human carcinoma cell lines: MCF-7, A-431, HaCaT, CaCo2
Clonality
Polyclonal
Specificity
Human desmoplakin 1
Purity/Purification
> 95% pure
Form/Format
Whole antiserum with 0.09% NaN3.
Concentration
50ul/vial (varies by lot)
Sequence Length
539
Applicable Applications for anti-desmoplakin antibody
Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes
ICC/IF: 1:100
IHC-P: 1:50
IHC-F: 1:50 (microwave treatment recommended, ABC method)
WB: 1:1,000
IHC-P: 1:50
IHC-F: 1:50 (microwave treatment recommended, ABC method)
WB: 1:1,000
Biological Significance
Desmoplakin is a protein associated with desmosomes. Desmoplakin is a protein that in humans is encoded by the DSP gene. Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin.
Immunogen
Human Desmoplakin 1 (C-terminus of recombinant human desmoplakin 1)
Cross Reactivity
Bovine, Human
Preparation and Storage
Store at 4°C short term.
-20°C long term.
Avoid repeated freeze-thaws.
-20°C long term.
Avoid repeated freeze-thaws.
Related Product Information for anti-desmoplakin antibody
Guinea Pig polyclonal Desmoplakin antibody
Product Categories/Family for anti-desmoplakin antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
desmoplakin
NCBI Official Symbol
desmoplakin
NCBI Protein Information
desmoplakin
UniProt Protein Name
Desmoplakin
Protein Family
UniProt Gene Name
desmoplakin
UniProt Entry Name
Q7T9S0_GVAO
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Product Notes
The desmoplakin desmoplakin (Catalog #AAA535037) is an Antibody produced from Guinea Pig and is intended for research purposes only. The product is available for immediate purchase. The Desmoplakin antibody reacts with The antiserum shows distinct punctate membrane staining of epithelia. In western blot analysis the antiserum reacts specifically with desmoplakin 1 polypeptide. Reacts to human carcinoma cell lines: MCF-7, A-431, HaCaT, CaCo2 and may cross-react with other species as described in the data sheet. AAA Biotech's Desmoplakin can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB). ICC/IF: 1:100 IHC-P: 1:50 IHC-F: 1:50 (microwave treatment recommended, ABC method) WB: 1:1,000. Researchers should empirically determine the suitability of the desmoplakin desmoplakin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Desmoplakin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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