Western Blot (WB)
(Anti-Desmoglein 3 antibody, MBS175691, Western blottingLane 1: A431 Cell LysateLane 2: CEM Cell Lysate )
Rabbit anti-Human Desmoglein 3 Polyclonal Antibody | anti-DSG3 antibody
Anti-Desmoglein 3 antibody
Western Blot (WB)
(Anti-Desmoglein 3 antibody, MBS175691, Western blottingLane 1: A431 Cell LysateLane 2: CEM Cell Lysate )
Western Blot (WB)
(Anti-Desmoglein 3 antibody, MBS175691, Western blottingLane 1: A431 Cell LysateLane 2: CEM Cell Lysate )
Background: Desmoglein3 is also known as PVA(Pemphigus Vulgaris Antigen). Pemphigus vulgaris(PV) and pemphigus foliaceus(PF) are autoimmune diseases of the skin which have as target antigens 2 different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen(PVA, or desmoglein-3) in the case of PV and desmoglein I in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.
NCBI and Uniprot Product Information
NCBI Description
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
Uniprot Description
DSG3: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: desmosome; plasma membrane; integral to membrane; cytosol
Molecular Function: calcium ion binding
Biological Process: apoptosis; homophilic cell adhesion; cell structure disassembly during apoptosis
Research Articles on DSG3
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Product Notes
The DSG3 dsg3 (Catalog #AAA175691) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Desmoglein 3 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Desmoglein 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the DSG3 dsg3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Desmoglein 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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