Rabbit DENTT Polyclonal Antibody | anti-TSPYL2 antibody
DENTT Polyclonal Antibody
This antibody recognizes human DENTT (Differentially Expressed Nucleolar TGF- beta 1 Target) protein, a gene product expressed in several normal tissues with the highest level of expression in brain. DENTT is involved in responses mediated by TGF- beta 1 and has distinct domains for direction to different subnuclear locations.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq]
Uniprot Description
TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.
Protein type: Transcription regulation; DNA replication
Chromosomal Location of Human Ortholog: Xp11.2
Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; nucleolus; nucleus
Molecular Function: rDNA binding
Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of signal transduction; chromatin modification; cell cycle; negative regulation of cell cycle; nucleosome assembly; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; negative regulation of DNA replication; negative regulation of cell growth; regulation of protein kinase activity
Research Articles on TSPYL2
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Product Notes
The TSPYL2 (Catalog #AAA194219) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DENTT can be used in a range of immunoassay formats including, but not limited to, Immunoblot. Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 77 kD is detected. Researchers should empirically determine the suitability of the TSPYL2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DENTT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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