Rabbit DENR Polyclonal Antibody | anti-DENR antibody

DENR Antibody

Cat. Num. AAA153601

• Gene Names: DENR; DRP; DRP1; SMAP-3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: DENR antibody is affinity chromatography purified via peptide column.
• Synonyms: DENR; Polyclonal Antibody; DENR Antibody; DRP; DRP1; SMAP-3; H14; Density-regulated protein; Protein DRP1; density-regulated protein; anti-DENR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DENR antibody is human, mouse and rat reactive.
• Purity/Purification: DENR antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 198

• Applicable Applications for anti-DENR antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: DENR antibody can be used for detection of DENR by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry at 5 mug/mL. For Immunoflorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: DENR antibody was raised against an 18 amino acid peptide near the center of human DENR.
• Buffer: DENR Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: DENR antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of DENR in human brain tissue lysate with DENR antibody at 1 μg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of DENR in rat brain tissue with DENR antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of DENR in rat brain tissue with DENR antibody at 20 μg/mL.)

Related Product Information for anti-DENR antibody

DENR (density-regulated protein), also designated DRP or smooth muscle cell associated protein 3 (SMAP-3), is a 198 amino acid protein that may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon (1). It plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 (2,3). DENR contains a SUI1 domain and is found in a variety of tissues with highest levels present in skeletal and cardiac muscle. It is up-regulated in ovarian and breast cancer cells by ERBB2 overexpression (4).

NCBI and Uniprot Product Information

• NCBI GI #: 27501446
• NCBI GeneID: 8562
• NCBI Accession #: NP_003668
• NCBI GenBank Nucleotide #: NM_003677.3
• UniProt Accession #: O43583; Q9H3U6; Q9UKZ0
• Molecular Weight: Predicted: 22 kDa; ; Observed: 22 kDa
• NCBI Official Full Name: density-regulated protein
• NCBI Official Synonym Full Names: density-regulated protein
• NCBI Official Symbol: DENR
• NCBI Official Synonym Symbols: DRP; DRP1; SMAP-3
• NCBI Protein Information: density-regulated protein; smooth muscle cell associated protein-3; smooth muscle cell-associated protein 3
• UniProt Protein Name: Density-regulated protein
• Protein Family: Density-regulated protein
• UniProt Gene Name: DENR
• UniProt Synonym Gene Names: DRP1; DRP; SMAP-3
• UniProt Entry Name: DENR_HUMAN

NCBI Description

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

Uniprot Description

DENR: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Plays a role in the modulation of the translational profile of a subset of cancer- related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. Belongs to the DENR family.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 12q24.31

Molecular Function: protein binding; translation initiation factor activity

Biological Process: ribosome disassembly; formation of translation preinitiation complex