Rabbit anti-Human DECR2 Polyclonal Antibody | anti-DECR2 antibody

DECR2 Antibody

Cat. Num. AAA9417304

• Gene Names: DECR2; PDCR; SDR17C1
• Reactivity: Human
• Applications: Western Blot
• Purity: Antigen affinity purification
• Synonyms: DECR2; Polyclonal Antibody; DECR2 Antibody; PDCR; SDR17C1; anti-DECR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total DECR2 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 0.5mg/ml (varies by lot)
• Sequence Length: 292

• Applicable Applications for anti-DECR2 antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:200-1000
• Immunogen: Fusion protein of human DECR2
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

SDS-Page

(Gel: 8%SDS-PAGE Lysate: 40 ug, Lane: HepG2 cell, Primary antibody:DECR2 antibody at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds)

Related Product Information for anti-DECR2 antibody

DECR2 (2,4-dienoyl-CoA reductase 2), also known as PDCR (peroxisomal 2,4-dienoyl-CoA reductase) or SDR17C1, is a 292 amino acid member of the short-chain dehydrogenases/reductases (SDR) protein family and the 2,4-dienoyl-CoA reductase protein subfamily. Localized to the peroxisome, DECR2 is an auxiliary enzyme of beta-oxidation that catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. DECR2 has also been shown to have catalytic activity towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA and short and medium chain 2,4-dienoyl-CoAs, suggesting that DECR2 is not a rate limiting step in the degradation of docosahexaenoic acid in the peroxisome. DECR2 is expressed as three isoforms produced by alternative splicing events.

Product Categories/Family for anti-DECR2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 10190704
• NCBI GeneID: 26063
• NCBI Accession #: NP_065715.1
• NCBI GenBank Nucleotide #: NM_020664.3
• UniProt Accession #: Q9NUI1; Q6ZRS7; Q96ET0
• Molecular Weight: 25,589 Da
• NCBI Official Full Name: peroxisomal 2,4-dienoyl-CoA reductase
• NCBI Official Synonym Full Names: 2,4-dienoyl-CoA reductase 2
• NCBI Official Symbol: DECR2
• NCBI Official Synonym Symbols: PDCR; SDR17C1
• NCBI Protein Information: peroxisomal 2,4-dienoyl-CoA reductase
• UniProt Protein Name: Peroxisomal 2,4-dienoyl-CoA reductase
• UniProt Gene Name: DECR2
• UniProt Synonym Gene Names: PDCR; SDR17C1; pDCR
• UniProt Entry Name: DECR2_HUMAN

Uniprot Description

DECR2: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.3.1.34; Oxidoreductase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: peroxisomal membrane

Molecular Function: 2,4-dienoyl-CoA reductase (NADPH) activity; receptor binding; trans-2-enoyl-CoA reductase (NADPH) activity

Biological Process: cellular lipid metabolic process; unsaturated fatty acid biosynthetic process