Rabbit anti-Human DDX41 Polyclonal Antibody | anti-DDX41 antibody

DDX41, NT (DDX41, ABS, Probable ATP-dependent RNA helicase DDX41, DEAD box protein 41, DEAD box protein abstrakt homolog) (PE)

Cat. Num. AAA6291485

• Gene Names: DDX41; ABS
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DDX41; Polyclonal Antibody; NT (DDX41; ABS; Probable ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD box protein abstrakt homolog) (PE); DEAD box protein abstrakt homolog; anti-DDX41 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-DDX41 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: DDX41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-169 amino acids from the N-terminal region of human DDX41.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(DDX41 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the DDX41 antibody detected the DDX41 protein (arrow).)

Related Product Information for anti-DDX41 antibody

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.

Product Categories/Family for anti-DDX41 antibody

Antibodies; DEAD Box Proteins

References

Wu, C., et al. Proteomics 7(11):1775-1785(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Olsen, J.V., et al. Cell 127(3):635-648(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006). Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 21071031
• NCBI GeneID: 51428
• NCBI Accession #: NP_057306.2
• NCBI GenBank Nucleotide #: NM_016222
• UniProt Accession #: Q9UJV9; Q96BK6; Q96K05; Q9NT96; Q9NW04; B2RDC8
• Molecular Weight: 69,838 Da
• NCBI Official Full Name: Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41), mRNA
• NCBI Official Synonym Full Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
• NCBI Official Symbol: DDX41
• NCBI Official Synonym Symbols: ABS
• NCBI Protein Information: probable ATP-dependent RNA helicase DDX41; 2900024F02Rik; DEAD box protein 41; DEAD box protein abstrakt homolog; DEAD-box protein abstrakt; putative RNA helicase
• UniProt Protein Name: Probable ATP-dependent RNA helicase DDX41
• Protein Family: Probable ATP-dependent RNA helicase
• UniProt Gene Name: DDX41
• UniProt Synonym Gene Names: ABS
• UniProt Entry Name: DDX41_HUMAN

NCBI Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

Uniprot Description

DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.

Protein type: Spliceosome; RNA-binding; RNA splicing; EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: membrane; endoplasmic reticulum; cytosol

Molecular Function: protein binding; DNA binding; zinc ion binding; helicase activity; ATP binding

Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; regulation of interferon type I production; apoptosis; multicellular organismal development; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; defense response to virus