Western Blot (WB)
(Western blot analysis of human bone marrow lysate (35ug protein in RIPA buffer) probed with DDX41 antibody (0.5ug/ml,MBS226144) and detected by chemiluminescence.)
Goat anti-Human DDX41 Polyclonal Antibody | anti-DDX41 antibody
Goat anti DDX41
0.02% Sodium Azide
0.5% Bovine Serum Albumin
Purified IgG - liquid
WB: 0.5ug/ml to 2ug/ml
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Western Blot (WB)
(Western blot analysis of human bone marrow lysate (35ug protein in RIPA buffer) probed with DDX41 antibody (0.5ug/ml,MBS226144) and detected by chemiluminescence.)
Western Blot (WB)
(Western blot analysis of human bone marrow lysate (35ug protein in RIPA buffer) probed with DDX41 antibody (0.5ug/ml,MBS226144) and detected by chemiluminescence.)
DDX41 is a helicase and a member of the DEAD-box family of proteins. It functions through the STING-TBK1-IRF3 pathway during innate immunity (Jiang et al. 2017) and is an important sensor of DNA viruses including HSV-1 and adenovirus, directly binding to DNA and STING via its DEADc domain (Zhang et al. 2011). DDX41 has been associated with hematological malignancies, with mutations in DDX41 identified in patients with myeloid neoplasms (Peters et al. 2017).
NCBI and Uniprot Product Information
NCBI Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]
Uniprot Description
DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.
Protein type: Spliceosome; RNA-binding; RNA splicing; EC 3.6.4.13; Helicase
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: membrane; endoplasmic reticulum; cytosol
Molecular Function: protein binding; DNA binding; zinc ion binding; helicase activity; ATP binding
Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; regulation of interferon type I production; apoptosis; multicellular organismal development; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; defense response to virus
Research Articles on DDX41
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Product Notes
The DDX41 ddx41 (Catalog #AAA226144) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti DDX41 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DDX41 can be used in a range of immunoassay formats including, but not limited to, Immunohistology-Paraffin (P), Western Blot (WB). P: 5ug/ml WB: 0.5ug/ml to 2ug/ml. Researchers should empirically determine the suitability of the DDX41 ddx41 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DDX41, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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