Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using DDX17 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Rabbit DDX17 Polyclonal Antibody | anti-DDX17 antibody
DDX17 Polyclonal Antibody
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using DDX17 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using DDX17 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
NCBI and Uniprot Product Information
NCBI Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]
Uniprot Description
DDX17: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation. Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytoplasm; cytosol; membrane; nuclear speck; nucleolus; nucleoplasm; nucleus
Molecular Function: ATP binding; ATP-dependent RNA helicase activity; protein binding; RNA binding; RNA helicase activity; RNA-dependent ATPase activity; transcription coactivator activity
Biological Process: alternative mRNA splicing, via spliceosome; androgen receptor signaling pathway; defense response to virus; epithelial to mesenchymal transition; intracellular estrogen receptor signaling pathway; miRNA metabolic process; myoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative mRNA splicing, via spliceosome; regulation of skeletal muscle cell differentiation; regulation of transcription from RNA polymerase II promoter; RNA processing; RNA secondary structure unwinding; RNA-mediated gene silencing; rRNA processing; transcription, DNA-dependent
Research Articles on DDX17
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Product Notes
The DDX17 ddx17 (Catalog #AAA2565874) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DDX17 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DDX17 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). IF: 1:50-1:200. Researchers should empirically determine the suitability of the DDX17 ddx17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DDX17, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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