Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (ntibody) at dilution 1/170.)
Rabbit anti-Human, Mouse DCAF1 Polyclonal Antibody | anti-DCAF1 antibody
DCAF1 Antibody
Gene Names
VPRBP; DCAF1
Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
DCAF1; Polyclonal Antibody; DCAF1 Antibody; RIP; VPRBP; anti-DCAF1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Antigen affinity purification
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
1.3mg/mL (varies by lot)
Applicable Applications for anti-DCAF1 antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:300
Immunogen
Fusion protein of human DCAF1
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C for 1 year.
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (ntibody) at dilution 1/170.)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (ntibody) at dilution 1/170.)
Related Product Information for anti-DCAF1 antibody
Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V (D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714).
Product Categories/Family for anti-DCAF1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
118,235 Da
NCBI Official Full Name
Homo sapiens Vpr (HIV-1) binding protein, mRNA
NCBI Official Synonym Full Names
Vpr (HIV-1) binding protein
NCBI Official Symbol
VPRBP
NCBI Official Synonym Symbols
DCAF1
NCBI Protein Information
protein VPRBP; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; serine/threonine-protein kinase VPRBP; vpr-interacting protein
UniProt Protein Name
Pancreatic lipase-related protein 1
UniProt Gene Name
PNLIPRP1
UniProt Synonym Gene Names
PLRP1
UniProt Entry Name
LIPR1_HUMAN
Research Articles on DCAF1
Similar Products
Product Notes
The DCAF1 pnliprp1 (Catalog #AAA9434810) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DCAF1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DCAF1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:300. Researchers should empirically determine the suitability of the DCAF1 pnliprp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCAF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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