Rabbit anti-Human DBNL Polyclonal Antibody | anti-DBNL antibody

DBNL, CT (DBNL, CMAP, SH3P7, Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55kD, SH3 domain-containing protein 7)

Cat. Num. AAA6007638

• Gene Names: DBNL; ABP1; HIP55; SH3P7; HIP-55
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: DBNL; Polyclonal Antibody; CT (DBNL; CMAP; SH3P7; Drebrin-like protein; Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55kD; SH3 domain-containing protein 7); Anti -DBNL; anti-DBNL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-DBNL antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: DBNL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-319 amino acids from the C-terminal region of human DBNL.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DBNL Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DBNL antibody detected the DBNL protein (arrow).)

Related Product Information for anti-DBNL antibody

Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.

Product Categories/Family for anti-DBNL antibody

Antibodies; Abs to Mucin

NCBI and Uniprot Product Information

• NCBI GI #: 546231646
• NCBI GeneID: 28988
• NCBI Accession #: NP_001271244.1
• NCBI GenBank Nucleotide #: NM_001284315.1
• UniProt Accession #: Q9UJU6; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; A4D2I9
• Molecular Weight: 48,207 Da
• NCBI Official Full Name: drebrin-like protein isoform e
• NCBI Official Synonym Full Names: drebrin-like
• NCBI Official Symbol: DBNL
• NCBI Official Synonym Symbols: ABP1; HIP55; SH3P7; HIP-55
• NCBI Protein Information: drebrin-like protein; drebrin-F; cervical SH3P7; SH3 domain-containing protein 7; cervical mucin-associated protein; HPK1-interacting protein of 55 kDa; src homology 3 domain-containing protein HIP-55
• UniProt Protein Name: Drebrin-like protein
• Protein Family: Drebrin-like protein
• UniProt Gene Name: DBNL
• UniProt Synonym Gene Names: CMAP; SH3P7; HIP-55
• UniProt Entry Name: DBNL_HUMAN

Uniprot Description

DBNL: an SH3-containing adaptor protein. Interacts with hematopoietic progenitor kinase 1a (HIPK1). It is recruited to glycolipid-enriched microdomains following T cell receptor (TCR) stimulation. Interacts with and is phosphorylated by ZAP-70 after TCR signaling. May regulate JNK activation following TCR signaling, presumably via its interaction with HIPKIt is a member of the drebrin family of proteins that are developmentally regulated in the brain.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: Golgi membrane; ruffle; lamellipodium; cytoplasm; dendrite; postsynaptic density; plasma membrane; clathrin coated vesicle membrane; podosome; cell cortex; cell junction; cytosol

Molecular Function: actin filament binding; protein C-terminus binding; protein domain specific binding; protein binding; enzyme activator activity; actin binding

Biological Process: receptor-mediated endocytosis; synaptogenesis; immune system process; apoptosis; Rac protein signal transduction; activation of JNK activity; neurite morphogenesis; cell structure disassembly during apoptosis