Western Blot (WB)
((2ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat DBH Polyclonal Antibody | anti-DBH antibody
Goat anti-DBH (aa437-448) Antibody
Western Blot: Approx 70kDa band observed in lysates of cell line Jurkat (calculated MW of 69.1kDa according to NP_000778.3). Recommended concentration: 1-3ug/ml.
Western Blot (WB)
((2ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((2ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
Uniprot Description
DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family.
Protein type: Membrane protein, integral; Apoptosis; EC 1.14.17.1; Amino Acid Metabolism - tyrosine; Motility/polarity/chemotaxis; Oxidoreductase; Cell cycle regulation
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: cytoplasm; extracellular region; integral to membrane; membrane
Molecular Function: catalytic activity; copper ion binding; dopamine beta-monooxygenase activity; L-ascorbic acid binding
Biological Process: behavioral response to ethanol; blood vessel remodeling; catecholamine biosynthetic process; cytokine production; dopamine catabolic process; fear response; glucose homeostasis; homoiothermy; leukocyte mediated immunity; leukocyte migration; locomotory behavior; maternal behavior; memory; norepinephrine biosynthetic process; positive regulation of vasoconstriction; regulation of cell proliferation; response to amphetamine; response to pain; synaptic transmission; visual learning
Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
Research Articles on DBH
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Product Notes
The DBH dbh (Catalog #AAA422807) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-DBH (aa437-448) Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's DBH can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 70kDa band observed in lysates of cell line Jurkat (calculated MW of 69.1kDa according to NP_000778.3). Recommended concentration: 1-3ug/ml. Researchers should empirically determine the suitability of the DBH dbh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DNHYSPHFQE IR. It is sometimes possible for the material contained within the vial of "DBH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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