Rabbit DAZ associated protein 1 Polyclonal Antibody | anti-DAZAP1 antibody
Rabbit anti-human DAZ associated protein 1 polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DAZAP1: a ubiquitous RNA-binding protein highly expressed in the human and the mouse testes. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm. Expressed at lower level in thymus and weakly expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. Fusion proteins between DAZAP1 and MEF2D have been observed in the TS-2 acute lymphoblastic leukemia (ALL) cell line. Two alternatively spliced isoforms have been described.
Protein type: RNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: RNA binding; nucleotide binding
Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; cell proliferation; spermatogenesis; cell differentiation; maternal placenta development
Research Articles on DAZAP1
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Product Notes
The DAZAP1 dazap1 (Catalog #AAA714895) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human DAZ associated protein 1 polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DAZ associated protein 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the DAZAP1 dazap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DAZ associated protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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