Rabbit anti-Human Cytochrome b-c1 complex subunit 8 Polyclonal Antibody | anti-b-c1 antibody

Rabbit anti-human Cytochrome b-c1 complex subunit 8 polyclonal Antibody

Cat. Num. AAA715150

• Gene Names: UQCRQ; QPC; QCR8; QP-C; UQCR7; MC3DN4
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G purified
• Synonyms: Cytochrome b-c1 complex subunit 8; Polyclonal Antibody; Rabbit anti-human Cytochrome b-c1 complex subunit 8 polyclonal Antibody; Cytochrome b-c1 Complex III subunit 8 Complex III subunit VIII Ubiquinol-cytochrome c reductase complex 9.5 kDa protein Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C; UQCRQ; anti-b-c1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid

• Applicable Applications for anti-b-c1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:1000-1:5000
• Immunogen: Recombinant Human Cytochrome b-c1 complex subunit 8 protein (2-78AA)
• Conjugate: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Species: Homo sapiens (Human)
• Research Area: Signal Transduction
• Target Names: UQCRQ
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: Cytochrome b-c1 complex subunit 8 antibody at 2ug/mlLane 1: EC109 whole cell lysateLane 2: 293T whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilutionPredicted band size: 10 kDaObserved band size: 30kDa)

Related Product Information for anti-b-c1 antibody

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

NCBI and Uniprot Product Information

• NCBI GI #: 83367083
• NCBI GeneID: 27089
• NCBI Accession #: NP_055217.2
• NCBI GenBank Nucleotide #: NM_014402.4
• UniProt Accession #: O14949; Q5FVE2; Q9BV88; Q9T2V7
• NCBI Official Full Name: cytochrome b-c1 complex subunit 8
• NCBI Official Synonym Full Names: ubiquinol-cytochrome c reductase complex III subunit VII
• NCBI Official Symbol: UQCRQ
• NCBI Official Synonym Symbols: QPC; QCR8; QP-C; UQCR7; MC3DN4
• NCBI Protein Information: cytochrome b-c1 complex subunit 8
• UniProt Protein Name: Cytochrome b-c1 complex subunit 8
• Protein Family: Cytochrome b-c1 complex
• UniProt Gene Name: UQCRQ
• UniProt Entry Name: QCR8_HUMAN

NCBI Description

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

Uniprot Description

UQCRQ: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. Defects in UQCRQ are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Belongs to the UQCRQ/QCR8 family.

Protein type: Mitochondrial; Oxidoreductase; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: mitochondrial inner membrane; mitochondrion

Molecular Function: ubiquinol-cytochrome-c reductase activity

Biological Process: cellular metabolic process; cerebellar Purkinje cell layer development; hippocampus development; hypothalamus development; midbrain development; pons development; pyramidal neuron development; subthalamus development; thalamus development

Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 4