Goat CYP26B1 Polyclonal Antibody | anti-CYP26B1 antibody

Goat Polyclonal to Human CYP26B1

Cat. Num. AAA243606

• Gene Names: CYP26B1; RHFCA; CYP26A2; P450RAI2; P450RAI-2
• Reactivity: Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat; Predicted Reactivity: Bat, Bovine, Dog, Pig (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CYP26B1; Polyclonal Antibody; Goat Polyclonal to Human CYP26B1; Anti-CYP26B1 Antibody (Internal) IHC-plus; Cytochrome P450RAI-2; Cytochrome P450 26B1; p450RAI2; RHFCA; CYP26A2; Cytochrome P450 26A2; p450RAI-2; Human CYP26B1; anti-CYP26B1 antibody

• Host: Goat
• Reactivity: Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat; Predicted Reactivity: Bat, Bovine, Dog, Pig (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CYP26B1.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 512

• Applicable Applications for anti-CYP26B1 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:128000), IHC-P (3.75 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-SQARSEDKDGRFH from an internal region of human CYP26B1 (NP_063938.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Horse, Rabbit (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: CYP26B1 antibody was raised against synthetic peptide C-SQARSEDKDGRFH from an internal region of human CYP26B1 (NP_063938.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Horse, Rabbit (100%); Panda, Bovine, Dog, Bat, Pig (92%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-CYP26B1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-CYP26B1 antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-CYP26B1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 9845285
• NCBI GeneID: 56603
• NCBI Accession #: NP_063938.1
• NCBI GenBank Nucleotide #: NM_019885.3
• UniProt Accession #: Q9NR63; Q32MC0; Q53TW1; Q9NP41; B2R8M7; B7Z2K6; B7Z2P4; B7Z3B8; E4W5W7
• Molecular Weight: 55,756 Da
• NCBI Official Full Name: cytochrome P450 26B1 isoform 1
• NCBI Official Synonym Full Names: cytochrome P450, family 26, subfamily B, polypeptide 1
• NCBI Official Symbol: CYP26B1
• NCBI Official Synonym Symbols: RHFCA; CYP26A2; P450RAI2; P450RAI-2
• NCBI Protein Information: cytochrome P450 26B1; retinoic acid-metabolizing cytochrome; cytochrome P450 retinoic acid-inactivating 2; cytochrome P450 retinoid metabolizing protein; cytochrome P450, subfamily XXVIB, polypeptide 1
• UniProt Protein Name: Cytochrome P450 26B1
• Protein Family: Cytochrome
• UniProt Gene Name: CYP26B1
• UniProt Synonym Gene Names: CYP26A2; P450RAI2; Cytochrome P450RAI-2
• UniProt Entry Name: CP26B_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Description

CYP26B1: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Defects in CYP26B1 are the cause of radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA). A disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects. Belongs to the cytochrome P450 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 1.14.-.-; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 2p13.2

Cellular Component: endoplasmic reticulum membrane; cytoplasm

Molecular Function: retinoic acid binding; iron ion binding; retinoic acid 4-hydroxylase activity; heme binding

Biological Process: retinoic acid receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; tongue morphogenesis; vitamin metabolic process; xenobiotic metabolic process; spermatogenesis; cell fate determination; male meiosis; proximal/distal pattern formation; embryonic limb morphogenesis

Disease: Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies