Goat anti-Human CYFIP1 Polyclonal Antibody | anti-CYFIP1 antibody

CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1, FLJ45151, KIAA0068, p140sra-1, SHYC, Specifically Rac1-associated Protein 1, SRA1, Sra-1)

Cat. Num. AAA623465

• Gene Names: CYFIP1; SHYC; SRA1; FLJ45151; P140SRA-1
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by peptide affinity chromatography.
• Synonyms: CYFIP1; Polyclonal Antibody; CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1; FLJ45151; KIAA0068; p140sra-1; SHYC; Specifically Rac1-associated Protein 1; SRA1; Sra-1); Anti -CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1; anti-CYFIP1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes CYFIP1. Species sequence homology: human, mouse, rat, canine, bovine. This antibody is expected to recognize isoform a (NP_055423.1) only.
• Purity/Purification: Affinity Purified; Purified by peptide affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-CYFIP1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: Peptide ELISA Titer: 1:2000
• Immunogen: Synthetic peptide corresponding to C-TGSGRQEAQKTDAE, from the internal region of human CYFIP1 (NP_055423.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-CYFIP1 antibody

Antibodies; Abs to DNA/RNA Translation

NCBI and Uniprot Product Information

• NCBI GI #: 74271907
• NCBI GeneID: 23191
• NCBI Accession #: NP_001028200.1
• NCBI GenBank Nucleotide #: NM_001033028.1
• UniProt Accession #: Q7L576; Q14467; Q5IED0; Q6ZSX1; Q9BSD9; Q9BVC7; A8K6D9
• Molecular Weight: 145,182 Da
• NCBI Official Full Name: cytoplasmic FMR1-interacting protein 1 isoform b
• NCBI Official Synonym Full Names: cytoplasmic FMR1 interacting protein 1
• NCBI Official Symbol: CYFIP1
• NCBI Official Synonym Symbols: SHYC; SRA1; FLJ45151; P140SRA-1
• NCBI Protein Information: cytoplasmic FMR1-interacting protein 1; sra-1; OTTHUMP00000159353; selective hybridizing clone; cytoplasmic FMRP interacting protein 1; specifically Rac1-associated protein 1
• UniProt Protein Name: Cytoplasmic FMR1-interacting protein 1
• Protein Family: Cytoplasmic FMR1-interacting protein
• UniProt Gene Name: CYFIP1
• UniProt Synonym Gene Names: KIAA0068
• UniProt Entry Name: CYFP1_HUMAN

Uniprot Description

CYFIP1: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. Belongs to the CYFIP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15q11

Cellular Component: ruffle; mRNA cap complex; neuron projection; focal adhesion; perinuclear region of cytoplasm; lamellipodium; synapse

Molecular Function: actin filament binding; protein binding; protein complex binding; Rac GTPase binding

Biological Process: lamellipodium biogenesis; regulation of cell shape; axon extension; ruffle organization and biogenesis; Rac protein signal transduction; cognition