Knockout Validation
(Knockout Validation: Lane 1: Wild-type A549 cell lysate; Lane 2: CCND1 knockout A549 cell lysate; Predicted MW: 33kDa Observed MW: 30kDa Primary Ab: 1ug/ml Rabbit Anti-Human CCND1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Cyclin D1 (CCND1) Polyclonal Antibody | anti-CCND1 antibody
Biotin-Linked Polyclonal Antibody to Cyclin D1 (CCND1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type A549 cell lysate; Lane 2: CCND1 knockout A549 cell lysate; Predicted MW: 33kDa Observed MW: 30kDa Primary Ab: 1ug/ml Rabbit Anti-Human CCND1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type A549 cell lysate; Lane 2: CCND1 knockout A549 cell lysate; Predicted MW: 33kDa Observed MW: 30kDa Primary Ab: 1ug/ml Rabbit Anti-Human CCND1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: bicellular tight junction; cyclin-dependent protein kinase holoenzyme complex; cytosol; intracellular; membrane; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: cyclin-dependent protein kinase activity; cyclin-dependent protein kinase regulator activity; enzyme binding; histone deacetylase binding; proline-rich region binding; protein binding; protein complex binding; protein kinase binding; transcription corepressor activity; transcription factor binding
Biological Process: cell division; cellular response to DNA damage stimulus; endoplasmic reticulum unfolded protein response; fat cell differentiation; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; mammary gland epithelial cell proliferation; negative regulation of cell cycle arrest; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt signaling pathway; positive regulation of cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein phosphorylation; protein amino acid phosphorylation; re-entry into mitotic cell cycle; response to calcium ion; response to corticosterone stimulus; response to drug; response to estradiol; response to estrogen; response to ethanol; response to iron ion; response to leptin; response to magnesium ion; response to organonitrogen compound; response to vitamin E; response to X-ray; transcription initiation from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
Disease: Myeloma, Multiple; Von Hippel-lindau Syndrome
Research Articles on CCND1
Similar Products
Product Notes
The CCND1 ccnd1 (Catalog #AAA2092188) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Cyclin D1 (CCND1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin D1 (CCND1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CCND1 ccnd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin D1 (CCND1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
