Western Blot (WB)
(Western Blot: Sample: Recombinant CREB, Human.)
Rabbit anti-Human Cyclic AMP Response Element Polyclonal Antibody | anti-CREB antibody
Polyclonal Antibody to Cyclic AMP Response Element Binding Protein (CREB)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- ISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant CREB, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant CREB, Human.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Uniprot Description
CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q33.3
Cellular Component: ATF4-CREB1 transcription factor complex; axon; mitochondrial matrix; nuclear euchromatin; nucleoplasm; nucleus
Molecular Function: DNA binding transcription factor activity; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; transcription cofactor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Biological Process: aging; axon guidance; cellular response to fatty acid; cellular response to insulin-like growth factor stimulus; cellular response to zinc ion; chemotaxis to arachidonic acid; circadian rhythm; lactation; memory; negative regulation of neuron death; negative regulation of transcription by competitive promoter binding; pituitary gland development; positive regulation of apoptosis; positive regulation of cardiac muscle tissue development; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of long-term synaptic potentiation; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transcriptional preinitiation complex assembly; positive regulation of transforming growth factor beta3 production; protein amino acid phosphorylation; protein kinase B signaling; protein stabilization; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; response to activity; response to drug; response to glucagon; response to hypoxia; response to L-glutamate; response to nicotine; response to organic substance; secretory granule organization and biogenesis; signal transduction; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral process; visual learning
Disease: Histiocytoma, Angiomatoid Fibrous
Research Articles on CREB
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Product Notes
The CREB creb1 (Catalog #AAA2026322) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cyclic AMP Response Element Binding Protein (CREB) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclic AMP Response Element can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the CREB creb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- ISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC. It is sometimes possible for the material contained within the vial of "Cyclic AMP Response Element, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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