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Immunohistochemistry (IHC) (Immunohistochemistry analysis of paraffin-embedded mouse spleen using CYBB Polyclonal Antibody at dilution of 1:400.)

Rabbit anti-Mouse, Rat CYBB Polyclonal Antibody | anti-CYBB antibody

CYBB Polyclonal Antibody

Gene Names
Cybb; Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox
Reactivity
Mouse, Rat
Applications
Immunohistochemistry
Purity
Affinity Purification
Synonyms
CYBB; Polyclonal Antibody; CYBB Polyclonal Antibody; AMCBX2; CGD; CGD91-phox; CY24B; Cytochrome b 245; beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit; anti-CYBB antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
Concentration
270 mug/mL (varies by lot)
Sequence Length
570
Applicable Applications for anti-CYBB antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:400-1:1200
Immunogen
Recombinant protein corresponding to Mouse NOX2
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse spleen using CYBB Polyclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC) (Immunohistochemistry analysis of paraffin-embedded mouse spleen using CYBB Polyclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded rat spleen using CYBB Polyclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC) (Immunohistochemistry analysis of paraffin-embedded rat spleen using CYBB Polyclonal Antibody at dilution of 1:400.)
Related Product Information for anti-CYBB antibody
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles.
Product Categories/Family for anti-CYBB antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
65,305 Da
NCBI Official Full Name
cytochrome b-245 heavy chain
NCBI Official Synonym Full Names
cytochrome b-245, beta polypeptide
NCBI Official Symbol
Cybb
NCBI Official Synonym Symbols
Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox
NCBI Protein Information
cytochrome b-245 heavy chain
UniProt Protein Name
Cytochrome b-245 heavy chain
Protein Family
UniProt Gene Name
Cybb
UniProt Synonym Gene Names
Cytochrome b558 subunit beta

NCBI Description

This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

Uniprot Description

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes.

Research Articles on CYBB

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Product Notes

The CYBB cybb (Catalog #AAA2556291) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CYBB Polyclonal Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CYBB can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:400-1:1200. Researchers should empirically determine the suitability of the CYBB cybb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYBB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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