Immunohistochemistry - Paraffin (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit CYBA / p22phox Polyclonal Antibody | anti-CYBA antibody
Anti-CYBA / p22phox Antibody IHC-plus
WB (1:500 - 1:1000)
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Immunohistochemistry - Paraffin (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
Western Blot (WB)
(Western blot (WB) analysis of Anti-p22phox pAb at 1:500 dilution. Lane1:MCF-7 whole cell lysate. Lane2:NIH-3T3 whole cell lysate. Lane3:PC12 whole cell lysate.)
Western Blot (WB)
(Western blot (WB) analysis of Anti-p22phox pAb at 1:500 dilution. Lane1:MCF-7 whole cell lysate. Lane2:NIH-3T3 whole cell lysate. Lane3:PC12 whole cell lysate.)
NCBI and Uniprot Product Information
NCBI Description
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
Uniprot Description
CYBA: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family.
Protein type: EC 1.-.-.-; Oxidoreductase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: apical plasma membrane; cell soma; dendrite; endosome; Golgi apparatus; membrane; mitochondrion; NADPH oxidase complex; phagocytic vesicle membrane; plasma membrane; secretory granule
Molecular Function: electron carrier activity; heme binding; metal ion binding; protein binding; protein heterodimerization activity; SH3 domain binding; superoxide-generating NADPH oxidase activity
Biological Process: angiotensin-mediated regulation of glomerular filtration; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cell redox homeostasis; cytochrome complex assembly; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of interleukin-6 production; positive regulation of phagocytosis; positive regulation of smooth muscle cell proliferation; positive regulation of superoxide release; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of tumor necrosis factor production; regulation of release of sequestered calcium ion into cytosol; respiratory burst; response to drug; response to nutrient levels; small GTPase mediated signal transduction; smooth muscle hypertrophy; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-negative
Research Articles on CYBA
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Product Notes
The CYBA cyba (Catalog #AAA249731) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CYBA / p22phox Antibody IHC-plus reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYBA / p22phox can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P (5 ug/ml) WB (1:500 - 1:1000). Researchers should empirically determine the suitability of the CYBA cyba for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYBA / p22phox, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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