Rabbit anti-Human CXCR6 Polyclonal Antibody | anti-CXCR6 antibody

CXCR6, NT (C-X-C Chemokine Receptor Type 6, CXC-R6, CXCR-6, CDw186, G-protein Coupled Receptor STRL33, G-protein Coupled Receptor Bonzo, CD186, BONZO, STRL33, TYMSTR)

Cat. Num. AAA6006858

• Gene Names: CXCR6; BONZO; CD186; STRL33; TYMSTR
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CXCR6; Polyclonal Antibody; NT (C-X-C Chemokine Receptor Type 6; CXC-R6; CXCR-6; CDw186; G-protein Coupled Receptor STRL33; G-protein Coupled Receptor Bonzo; CD186; BONZO; STRL33; TYMSTR); Anti -CXCR6; anti-CXCR6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human STRL33.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-CXCR6 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1:500; Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml
• Immunogen: Synthetic peptide corresponding to the N-terminal of human Bonzo/STRL33 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Thymus (formalin-fixed, paraffin-embedded) stained with CXCR6 antibody at 2.5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Western Blot (WB)

(Western blot analysis of Bonzo in human spleen tissue lysate in the absence (lane A) or presence (lane B) of peptide with Bonzo antibody at 1 µg/ml.)

Related Product Information for anti-CXCR6 antibody

Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use other chemokine receptors, such as CXCR6, a T-lymphocyte-expressed seven-transmembrane domain receptor that mediates fusion, entry, and trafficking of tumor-infiltrating lymphocytes. CXCR6 has been identified in human blood (T-lymphocytes, activated peripheral blood lymphocytes, monocyte-derived dendritic cells, primitive cord blood cells), placental trophoblasts, T-lymphocytes and dendritic cells in the skin, lymphoid tissues, and in fetal brain astrocytes. ESTs have been isolated from human normal placenta, liver/spleen, and pregnant uterus libraries, and human cancer kidney and uterus libraries.

Product Categories/Family for anti-CXCR6 antibody

Antibodies; Abs to G Protein Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 5730106
• NCBI GeneID: 10663
• NCBI Accession #: NP_006555.1
• NCBI GenBank Nucleotide #: NM_006564.1
• UniProt Accession #: O00574; O00575; Q9HCA5
• Molecular Weight: 39,280 Da
• NCBI Official Full Name: C-X-C chemokine receptor type 6
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 6
• NCBI Official Symbol: CXCR6
• NCBI Official Synonym Symbols: BONZO; CD186; STRL33; TYMSTR
• NCBI Protein Information: C-X-C chemokine receptor type 6; CDw186; CXC-R6; CXCR-6; G protein-coupled receptor; G-protein coupled receptor bonzo; G-protein coupled receptor STRL33
• UniProt Protein Name: C-X-C chemokine receptor type 6
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: CXCR6
• UniProt Synonym Gene Names: BONZO; STRL33; TYMSTR; CXC-R6; CXCR-6
• UniProt Entry Name: CXCR6_HUMAN

Uniprot Description

CXCR6: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; coreceptor activity; C-X-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; viral genome replication; inflammatory response; chemotaxis