Rabbit anti-Human CXCR6 Polyclonal Antibody | anti-CXCR6 antibody

CXCR6, NT (CXCR6, BONZO, STRL33, TYMSTR, C-X-C chemokine receptor type 6, CDw186, G-protein coupled receptor STRL33, G-protein coupled receptor bonzo, CD186) (Azide free) (HRP)

Cat. Num. AAA6290258

• Gene Names: CXCR6; BONZO; CD186; STRL33; TYMSTR
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CXCR6; Polyclonal Antibody; NT (CXCR6; BONZO; STRL33; TYMSTR; C-X-C chemokine receptor type 6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD186) (Azide free) (HRP); CD186; anti-CXCR6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-CXCR6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CXCR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human CXCR6.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CXCR6 Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CXCR6 antibody detected the CXCR6 protein (arrow).)

Related Product Information for anti-CXCR6 antibody

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Product Categories/Family for anti-CXCR6 antibody

Antibodies; CD Markers

References

Limou, S., et al. J. Infect. Dis. 202(6):908-915(2010). Zhou, W.H., et al. Zhonghua Yi Xue Za Zhi 90(14):947-951(2010). Segat, L., et al. Vaccine 28(10):2201-2206(2010). Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010): Darash-Yahana, M., et al. PLoS ONE 4 (8), E6695 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 5730106
• NCBI GeneID: 10663
• NCBI Accession #: NP_006555.1
• NCBI GenBank Nucleotide #: NM_006564.1
• UniProt Accession #: O00574; O00575; Q9HCA5
• Molecular Weight: 39,280 Da
• NCBI Official Full Name: C-X-C chemokine receptor type 6
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 6
• NCBI Official Symbol: CXCR6
• NCBI Official Synonym Symbols: BONZO; CD186; STRL33; TYMSTR
• NCBI Protein Information: C-X-C chemokine receptor type 6; CDw186; CXC-R6; CXCR-6; G protein-coupled receptor; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo
• UniProt Protein Name: C-X-C chemokine receptor type 6
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: CXCR6
• UniProt Synonym Gene Names: BONZO; STRL33; TYMSTR; CXC-R6; CXCR-6
• UniProt Entry Name: CXCR6_HUMAN

Uniprot Description

CXCR6: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; coreceptor activity; C-X-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; viral genome replication; inflammatory response; chemotaxis