Rabbit CXCR5 Polyclonal Antibody | anti-CXCR5 antibody

Rabbit Polyclonal to Human CXCR5

Cat. Num. AAA243498

• Gene Names: CXCR5; BLR1; CD185; MDR15
• Reactivity: Gorilla, Human; Predicted Reactivity: Monkey, Hamster (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CXCR5; Polyclonal Antibody; Rabbit Polyclonal to Human CXCR5; Anti-CXCR5 Antibody (C-Terminus) IHC-plus; CD185 antigen; CD185; CXCR-5; CXC-R5; GPR9; MDR15; Monocyte-derived receptor 15; Blr-1; BLR1; Burkitt lymphoma receptor 1; Burkitt's lymphoma receptor 1; MDR-15; Human CXCR5; anti-CXCR5 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Monkey, Hamster (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CXCR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NAAA (67%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 372

• Applicable Applications for anti-CXCR5 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from C-terminus of human CXCR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Hamster (94%); Gibbon, Mouse, Rat, Dog, Bovine, Panda, Pig (89%).
• Immunogen Type: Synthetic peptide
• Immunogen: CXCR5 antibody was raised against synthetic 18 amino acid peptide from C-terminus of human CXCR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Hamster (94%); Gibbon, Mouse, Rat, Dog, Bovine, Panda, Pig (89%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CXCR5 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CXCR5 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CXCR5 antibody IHC of human Small Intestine, B-Cell, Burkitt Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CXCR5 antibody IHC of human Lymph Node, B-Cell, Mantle Cell Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CXCR5 antibody

CXCR5, a Chemokine Receptor, also called Burkitt's lymphoma receptor 1, is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. CXCR5 binds B-lymphocyte chemoattractant (BLC) and is involved in B-cell homing to follicles in lymph nodes and spleen. Two isoforms are produced by alternative splicing.

Product Categories/Family for anti-CXCR5 antibody

Family: GPCR; Subfamily: Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 4502415
• NCBI GeneID: 643
• NCBI Accession #: NP_001707.1
• NCBI GenBank Nucleotide #: NM_001716.4
• UniProt Accession #: P32302; Q14811
• Molecular Weight: 36,676 Da
• NCBI Official Full Name: C-X-C chemokine receptor type 5 isoform 1
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 5
• NCBI Official Symbol: CXCR5
• NCBI Official Synonym Symbols: BLR1; CD185; MDR15
• NCBI Protein Information: C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; MDR-15; monocyte-derived receptor 15; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
• UniProt Protein Name: C-X-C chemokine receptor type 5
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: CXCR5
• UniProt Synonym Gene Names: BLR1; MDR15; CXC-R5; CXCR-5; MDR-15
• UniProt Entry Name: CXCR5_HUMAN

NCBI Description

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; chemotaxis; cell motility; lymph node development