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Testing Data

Rabbit CXCR4 Polyclonal Antibody | anti-CXCR4 antibody

CXCR4 Antibody

Gene Names
Cxcr4; CD184; LESTR; Sdf1r; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Affinity purified
Synonyms
CXCR4; Polyclonal Antibody; CXCR4 Antibody; chemokine C-X-C motif receptor 4; chemokine receptor 4; anti-CXCR4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-CXCR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
359
Applicable Applications for anti-CXCR4 antibody
Western Blot (WB)
Application Notes
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately.
Immunogen
Synthetic peptide surrounding amino acid 18 of mouse CXCR4
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months

Testing Data

Testing Data
Related Product Information for anti-CXCR4 antibody
Background: CXCR4 (fusin) is a member in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 thromugh the viral envelope glycoprotein gp120. In other cases, CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells. A mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
40,240 Da
NCBI Official Full Name
C-X-C chemokine receptor type 4
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 4
NCBI Official Symbol
Cxcr4
NCBI Official Synonym Symbols
CD184; LESTR; Sdf1r; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
NCBI Protein Information
C-X-C chemokine receptor type 4
UniProt Protein Name
C-X-C chemokine receptor type 4
Protein Family
UniProt Gene Name
Cxcr4
UniProt Synonym Gene Names
Cmkar4; Lestr; Sdf1r; CXC-R4; CXCR-4; LESTR; PB-CKR; SDF-1 receptor
UniProt Entry Name
CXCR4_MOUSE

Uniprot Description

CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cell surface; lysosome; leading edge; early endosome; cytoplasmic membrane-bound vesicle; integral to membrane; intercellular junction; growth cone; membrane; late endosome; plasma membrane; cytoplasmic vesicle; cell junction; endosome; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; cytokine binding; chemokine receptor activity; myosin light chain binding; drug binding; actin binding; C-X-C chemokine receptor activity

Biological Process: nervous system development; cell migration; regulation of chemotaxis; neutrophil activation; calcium-mediated signaling; neuron migration; motor axon guidance; regulation of programmed cell death; regulation of calcium ion transport; signal transduction; chemotaxis; regulation of cell migration; germ cell development; T cell proliferation; patterning of blood vessels; G-protein coupled receptor protein signaling pathway; organ morphogenesis; ameboidal cell migration; myelin maintenance; germ cell migration; epithelial cell development; brain development; positive regulation of oligodendrocyte differentiation; cardiac muscle contraction; telencephalon cell migration

Research Articles on CXCR4

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Product Notes

The CXCR4 cxcr4 (Catalog #AAA841043) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CXCR4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CXCR4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately. Researchers should empirically determine the suitability of the CXCR4 cxcr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCR4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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