Rabbit anti-Human, Mouse CTSF Polyclonal Antibody | anti-CTSF antibody

CTSF Antibody

Cat. Num. AAA9429696

• Gene Names: CTSF; CATSF; CLN13
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CTSF; Polyclonal Antibody; CTSF Antibody; CATSF; CLN13; anti-CTSF antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total CTSF protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 0.7mg/ml (varies by lot)
• Sequence Length: 484

• Applicable Applications for anti-CTSF antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 20-100
• Immunogen: Synthetic peptide corresponding to internal residues of human CTSF
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 46549(CTSF Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200))

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46549(CTSF Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200))

Related Product Information for anti-CTSF antibody

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Product Categories/Family for anti-CTSF antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 6042196
• NCBI GeneID: 8722
• NCBI Accession #: NP_003784
• NCBI GenBank Nucleotide #: NM_003793.3
• UniProt Accession #: Q9UBX1; O95240; Q9NSU4; Q9UKQ5; B2R964
• Molecular Weight: 53,366 Da
• NCBI Official Full Name: cathepsin F
• NCBI Official Synonym Full Names: cathepsin F
• NCBI Official Symbol: CTSF
• NCBI Official Synonym Symbols: CATSF; CLN13
• NCBI Protein Information: cathepsin F
• UniProt Protein Name: Cathepsin F
• Protein Family: Cathepsin
• UniProt Gene Name: CTSF
• UniProt Synonym Gene Names: CATSF

NCBI Description

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]

Uniprot Description

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.