Rabbit anti-Human CTPS2 Polyclonal Antibody | anti-CTPS2 antibody

CTPS2 Antibody; Biotin conjugated

Cat. Num. AAA7006683

• Reactivity: Human
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: CTPS2; Polyclonal Antibody; CTPS2 Antibody; Biotin conjugated; CTP synthase 2; CTP synthetase 2; UTP--ammonia ligase 2; anti-CTPS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 586

• Applicable Applications for anti-CTPS2 antibody: ELISA (EIA)
• Immunogen: Recombinant human CTP synthase 2 protein
• Conjugation: Biotin
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-CTPS2 antibody

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.

NCBI and Uniprot Product Information

• NCBI GI #: 221316689
• NCBI GeneID: 56474
• NCBI Accession #: NP_001137474.1
• NCBI GenBank Nucleotide #: NM_001144002.1
• UniProt Accession #: Q9NRF8; Q9BRI0; Q9H809; Q9H8K9; B3KWM2
• Molecular Weight: 65,678 Da
• NCBI Official Full Name: CTP synthase 2
• NCBI Official Synonym Full Names: CTP synthase 2
• NCBI Official Symbol: CTPS2
• NCBI Protein Information: CTP synthase 2
• UniProt Protein Name: CTP synthase 2
• Protein Family: CTP synthase
• UniProt Gene Name: CTPS2
• UniProt Entry Name: PYRG2_HUMAN

NCBI Description

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

CTPS2: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. Belongs to the CTP synthase family.

Protein type: Nucleotide Metabolism - pyrimidine; EC 6.3.4.2; Ligase

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: cytosol; mitochondrion

Molecular Function: ATP binding; CTP synthase activity; protein binding

Biological Process: glutamine metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process