Rabbit anti-Human, Mouse CTNNA3 Polyclonal Antibody | anti-CTNNA3 antibody

CTNNA3 (Catenin alpha-3, Alpha T-catenin, Cadherin-associated Protein) (PE)

Cat. Num. AAA6375016

• Gene Names: CTNNA3; VR22; ARVD13
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CTNNA3; Polyclonal Antibody; CTNNA3 (Catenin alpha-3; Alpha T-catenin; Cadherin-associated Protein) (PE); anti-CTNNA3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CTNNA3. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 1824

• Applicable Applications for anti-CTNNA3 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human CTNNA3, aa1-516 (AAH65819.1).
• Immunogen Sequence: MSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQEATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDVASLKASKDTVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNIALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKNGREKEIKEYAAIFHEHTSRLVEVANLACSMSTNEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAVKNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSGMFLFF
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CTNNA3 rabbit polyclonal antibody. Western Blot analysis of CTNNA3 expression in mouse spleen.)

Western Blot (WB)

(Western Blot analysis of CTNNA3 expression in transfected 293T cell line by CTNNA3 polyclonal antibody. Lane 1: CTNNA3 transfected lysate (57.3kD). Lane 2: Non-transfected lysate.)

Testing Data

(Proximity Ligation Analysis (PLA) of protein-protein interactions between CTNNA3 and CTNNB1. HeLa cells were stained with CTNNA3 rabbit purified polyclonal 1:1200 and CTNNB1 mouse monoclonal antibody 1:50. Signals were detected 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)

Related Product Information for anti-CTNNA3 antibody

Alpha-catenins stabilize the cell-cell contacts by functioning as a molecular switch that regulates actin dynamics at the site of the adherens junction. Alpha-T Catenin is involved in the formation of stretch-resistant cell-cell adhesion complexes. Alpha-T catenin is expressed predominantly in cardiomyocytes, where it colocalizes with alpha-E catenin at the intercalated discs. Moreover, alpha-T Catenin is also expressed in the brain and inhibits Wnt signaling, so it is implicated in Alzheimer's disease.

Product Categories/Family for anti-CTNNA3 antibody

Antibodies; Catenin

NCBI and Uniprot Product Information

• NCBI GI #: 41350932
• NCBI GeneID: 29119
• NCBI Official Full Name: Homo sapiens catenin (cadherin-associated protein), alpha 3, mRNA
• NCBI Official Synonym Full Names: catenin alpha 3
• NCBI Official Symbol: CTNNA3
• NCBI Official Synonym Symbols: VR22; ARVD13
• NCBI Protein Information: catenin alpha-3
• Protein Family: Catenin

NCBI Description

This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]